Results 81 to 90 of about 1,686,019 (401)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites

Molecular Metabolism, 2018
Objectives: 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract.
Mari L. Lund, Kristoffer L. Egerod, Maja S. Engelstoft, Oksana Dmytriyeva, Elvar Theodorsson, Bhavik A. Patel, Thue W. Schwartz   +6 more
doaj   +1 more source

Absolute Metabolite Concentrations and Implied Enzyme Active Site Occupancy in Escherichia coli

Nature Chemical Biology, 2009
Absolute metabolite concentrations are critical to a quantitative understanding of cellular metabolism, as concentrations impact both the free energies and rates of metabolic reactions.
Bryson D. Bennett, Elizabeth H Kimball, Melissa Gao, R. Osterhout, S. Van Dien, Joshua D. Rabinowitz   +5 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry : application to the characterisation of metabolites in rat urine [PDF]

, 2019
A comprehensive Collision Cross Section (CCS) library was obtained via Travelling Wave Ion Guide mobility measurements through direct infusion (DI). The library consists of CCS and Mass Spectral (MS) data in negative and positive ElectroSpray Ionisation (
Bouwmeester, Robbin, Coen, Muireann, Gethings, Lee A, Lai, Steven, Langridge, James I, Letertre, Marine PM, Martens, Lennart, McCullagh, Michael, Munjoma, Nyasha C, Nicholson, Jeremy K, Nye, Leanne C, Plumb, Robert S, Swann, Jonathan R, Vissers, Johannes PC, Williams, Jonathan P, Wilson, Ian D   +15 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Real-time monitoring and in vivo visualization of acetylcholinesterase activity with a near-infrared fluorescent probe

Journal of Pharmaceutical Analysis
Acetylcholinesterase (AChE) plays a crucial role in the activities of the nervous system, and its abnormal function can lead to the occurrence and development of neurodegenerative diseases.
Keyun Zeng, Fang Fan, Yuqi Tang, Xiaoyu Wang, Diya Lv, Jieman Lin, Yuxin Zhang, Yingying Zhu, Yifeng Chai, Xiaofei Chen, Quan Li   +10 more
doaj   +1 more source

Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS

Journal of Lipid Research, 2015
Tocopherols and tocotrienols are metabolized via hydroxylation and oxidation of their hydrophobic side chain to generate 13′-hydroxychromanols (13′-OHs) and various carboxychromanols, which can be further metabolized by conjugation including sulfation ...
Qing Jiang, Tianlin Xu, Jianjie Huang, Amber S. Jannasch, Bruce Cooper, Chao Yang   +5 more
doaj   +1 more source

An in vitro model of the chicken gastrointestinal tract with special emphasis to the cecal microbiota

Poultry Science, 2023
: An in vitro model of the upper gastrointestinal tract as well as the chicken cecum was developed to have a predictive tool for estimating the production performance of animals by analyzing the feeding value of a certain diet. The upper gastrointestinal
Sofia D. Forssten, Wesley Morovic, Päivi Nurminen   +2 more
doaj   +1 more source

Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics

Nature Communications, 2019
Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics. Here, we develop a metabolic reaction network (MRN)-based recursive algorithm (MetDNA) that expands metabolite annotations ...
Xiaotao Shen, Ruohong Wang, Xin Xiong, Yandong Yin, Yuping Cai, Zaijun Ma, Nan Liu, Zheng-Jiang Zhu   +7 more
semanticscholar   +1 more source