Results 61 to 70 of about 639,967 (307)

Real-time monitoring and in vivo visualization of acetylcholinesterase activity with a near-infrared fluorescent probe

Journal of Pharmaceutical Analysis
Acetylcholinesterase (AChE) plays a crucial role in the activities of the nervous system, and its abnormal function can lead to the occurrence and development of neurodegenerative diseases.
Keyun Zeng, Fang Fan, Yuqi Tang, Xiaoyu Wang, Diya Lv, Jieman Lin, Yuxin Zhang, Yingying Zhu, Yifeng Chai, Xiaofei Chen, Quan Li   +10 more
doaj   +1 more source

Analysis of vitamin E metabolites including carboxychromanols and sulfated derivatives using LC/MS/MS

Journal of Lipid Research, 2015
Tocopherols and tocotrienols are metabolized via hydroxylation and oxidation of their hydrophobic side chain to generate 13′-hydroxychromanols (13′-OHs) and various carboxychromanols, which can be further metabolized by conjugation including sulfation ...
Qing Jiang, Tianlin Xu, Jianjie Huang, Amber S. Jannasch, Bruce Cooper, Chao Yang   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps-1

, 2011
CA/K-means (HcaAL/Kmeans) and complete linkage (HcaCL/Kmeans) for different numbers of prototypes.Copyright information:Taken from "Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps"http ...
Peter Meinicke (18061), Cornelia Göbel (94444), Alexander Kaever (94442), Petr Karlovsky (72651), Kirstin Feussner (94443), Thomas Lingner (93705), Ivo Feussner (94445), Burkhard Morgenstern (7977)   +7 more
core   +1 more source

An in vitro model of the chicken gastrointestinal tract with special emphasis to the cecal microbiota

Poultry Science, 2023
: An in vitro model of the upper gastrointestinal tract as well as the chicken cecum was developed to have a predictive tool for estimating the production performance of animals by analyzing the feeding value of a certain diet. The upper gastrointestinal
Sofia D. Forssten, Wesley Morovic, Päivi Nurminen   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

An exome array study of the plasma metabolome

Nature Communications, 2016
Several GWAS have identified many common variants associated with blood metabolites. Here, the authors use an exome array to identify low frequency, potentially functional variants that impact human metabolism.
Eugene P. Rhee, Qiong Yang, Bing Yu, Xuan Liu, Susan Cheng, Amy Deik, Kerry A. Pierce, Kevin Bullock, Jennifer E. Ho, Daniel Levy, Jose C. Florez, Sek Kathiresan, Martin G. Larson, Ramachandran S. Vasan, Clary B. Clish, Thomas J. Wang, Eric Boerwinkle, Christopher J. O’Donnell, Robert E. Gerszten   +18 more
doaj   +1 more source

Volatile Metabolites [PDF]

Metabolites, 2011
Volatile organic compounds (volatiles) comprise a chemically diverse class of low molecular weight organic compounds having an appreciable vapor pressure under ambient conditions. Volatiles produced by plants attract pollinators and seed dispersers, and provide defense against pests and pathogens.
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Integrative analyses of genetic variation in enzyme activities of primary carbohydrate metabolism reveal distinct modes of regulation in Arabidopsis thaliana [PDF]

, 2008
Background Plant primary carbohydrate metabolism is complex and flexible, and is regulated at many levels. Changes of transcript levels do not always lead to changes in enzyme activities, and these do not always affect metabolite levels and fluxes.
Fu, Jingyuan, Vreugdenhil, Dick, Fu, Jingyuan; id_orcid, Keurentjes, Joost Jb, Keurentjes, J. J. B., Steinhauser, Marie-Caroline, Koornneef, Maarten, Koornneef, M., Steinhauser, M. C., Steinhauser, M., Steinhauser, C., Keurentjes, Joost J. B., Keurentjes, J., Gibon, Y., Keurentjes, J.J.B., Sulpice, R., Gibon, Yves, Stitt, M., Steinhauser, M.C., Sulpice, Ronan, Vreugdenhil, D., Fu, J. Y., Fu, J., Stitt, Mark   +23 more
core   +1 more source