Results 61 to 70 of about 1,686,019 (401)

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. [PDF]

, 2017
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and ...
Berger, Mitchel S, Chang, Susan M, Crane, Jason C, Elkhaled, Adam, Jalbert, Llewellyn E, Kurhanewicz, John, Molinaro, Annette M, Neill, Evan, Nelson, Sarah J, Olson, Marram P, Phillips, Joanna J, Ronen, Sabrina M, Williams, Aurelia   +12 more
core   +1 more source

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

Nucleic Acids Res., 2011
Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol-lowering drugs.
M. Medema, K. Blin, Peter Cimermancic, V. D. Jager, Piotr Zakrzewski, M. Fischbach, T. Weber, E. Takano, R. Breitling   +8 more
semanticscholar   +1 more source

Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy. [PDF]

, 2016
People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many phthalates are endocrine disruptors and have been associated with adverse health outcomes.
Bradman, Asa, Eskenazi, Brenda, Holland, Nina, Huen, Karen, Nguyen, Brian, Street, Kelly, Tran, Vy   +6 more
core   +3 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
A Collins, A Cougnoux, AO Brachmann, BR Stern, Bradley S. Moore, CA Brotherton, CA Brotherton, CM Woo, D Payros, E Buc, EP Balskus, EP Rogakou, G Cuevas-Ramos, G Sharon, HB Bode, I Cho, J Chen, JA Stubbe, JC Arthur, Jennifer Y. H. Lai, Jie Li, JK Nicholson, JP Nougayrède, KJ Humphreys, KK Khanna, KS Chaturvedi, L Zha, L Zha, LB Schultz, LC Colis, LF Povirk, M Olier, M Pitie, MI Vizcaino, MI Vizcaino, MR Wilson, MS Donia, MS Donia, MS Melvin, N Bossuet-Greif, N Bossuet-Greif, NS Guntaka, P Engel, P Tripathi, Pei-Yuan Qian, RM Bleich, RM Burger, S Borah, S Tomkovich, Shaun M. K. McKinnie, T Faïs, T Pérez-Berezo, T Secher, TC Holmes, V Bondarev, Wei-Peng Zhang, Wenjun Zhang, Wenlong Cai, X Bian, X Bian, Y Pommier, YA Chan, Z-R Li, Z-R Li, Zhong-Rui Li   +64 more
core   +1 more source

Transportable hyperpolarized metabolites [PDF]

Nature Communications, 2017
Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao, Bornet, Aurélien, Vuichoud, Basile, Milani, Jonas, Gajan, David, Rossini, Aaron J., Emsley, Lyndon, Bodenhausen, Geoffrey, Jannin, Sami   +8 more
openaire   +6 more sources

Organic Bioelectronic Devices for Metabolite Sensing.

Chemical Reviews, 2021
Electrochemical detection of metabolites is essential for early diagnosis and continuous monitoring of a variety of health conditions. This review focuses on organic electronic material-based metabolite sensors and highlights their potential to tackle ...
Anil Koklu, D. Ohayon, Shofarul Wustoni, Victor Druet, Abdulelah Saleh, S. Inal   +5 more
semanticscholar   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Automated method for study of drug metabolism [PDF]

, 1973
Commercially available equipment can be modified to provide automated system for assaying drug metabolism by continuous flow-through. System includes steps and devices for mixing drug with enzyme and cofactor in the presence of pure oxygen, dialyzing ...
Feller, D. D., Furner, R. L.
core   +1 more source

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease [PDF]

, 2014
Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may reach epidemic proportions over the next decade. Efforts have been made to improve diagnosis and management of CKD.
Argilés, Àngel, Dakna, Mohammed, Delles, Christian, Duranton, Flore, Gayrard, Nathalie, Husi, Holger, Klein, Julie, Koeck, Thomas, Lundin, Ulrika, Mischak, Harald, Mullen, William, Nkuipou-Kenfack, Esther, Weinberger, Klaus M., Zürbig, Petra   +13 more
core   +5 more sources