Results 51 to 60 of about 1,686,019 (401)

Isoflavones' effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats

open access: yesJournal of Pharmaceutical Analysis, 2020
Gardeniae Fructus (GF) and Semen Sojae Praeparatum (SSP) are both medicine food homologies and widely used in Chinese clinical prescriptions together. The research investigated the pharmacokinetics of four iridoids in normal rats and isolfavones-fed rats,
Ruirui Chang   +7 more
doaj   +1 more source

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

open access: yes, 2007
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin   +17 more
core   +2 more sources

DDT and Metabolites

open access: yes, 2015
Dichlorodiphenyltrichloroethane (DDT) is a well-known insecticide that was introduced and widely used during World War II. In total more than 4.5 million tonnes DDT have been produced. Although its use and production stopped worldwide during the 1970s, it was reintroduced in the 2000s as a malaria vector control by the World Health Organization (WHO ...
Mirmigkou, S., de Boer, J.
openaire   +3 more sources

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

open access: yesPharmacological Reviews, 2018
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. Although best characterized for its dissociative anesthetic properties, ketamine also exerts analgesic, anti-inflammatory, and antidepressant actions ...
P. Zanos   +10 more
semanticscholar   +1 more source

High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates

open access: yesMolecules, 2017
Sodium Danshensu (sodium d-(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza, exhibits potent relaxation of the coronary artery and anticoagulation effection.
Jingjing Jiang   +6 more
doaj   +1 more source

Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis. [PDF]

open access: yes, 2014
ImportanceWhile "omics" studies have advanced our understanding of inflammatory skin diseases, metabolomics is mostly an unexplored field in dermatology.ObjectiveWe sought to elucidate the pathogenesis of psoriatic diseases by determining the differences
Armstrong, April W   +6 more
core   +2 more sources

Comprehensive metabolomic and lipidomic alterations in response to heat stress during seed germination and seedling growth of Arabidopsis

open access: yesFrontiers in Plant Science, 2023
Temperature affects seed germination and seedling growth, which is a critical and complex stage in plant life cycle. However, comprehensive metabolic basis on temperature implicating seed germination and seedling growth remains less known.
Wenjuan Qian   +7 more
doaj   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

open access: yes, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum   +5 more
core   +2 more sources

Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

open access: yesCell, 2016
SUMMARY Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events.
Weifei Zhu   +19 more
semanticscholar   +1 more source

Advances in sensor developments for cell culture monitoring

open access: yesBMEMat, 2023
Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture ...
Ka Ram Kim, Woon‐Hong Yeo
doaj   +1 more source

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