Results 71 to 80 of about 639,967 (307)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimization of conditions and in vitro antibacterial activity of secondary metabolite isolated from Streptomyces sp. MNK7

, 2010
Streptomyces sp. MNK7 was isolated from Natore, Bangladesh. Morphological, physiological and biochemical studies strongly suggested that the isolate belonged to Streptomyces.
Ripa, F.A., Khondkar, P., Saha, M.R., Islam, M.A.   +3 more
core   +3 more sources

Gut Microbiota, a Potential Mediated Target for Reducing Geniposide Hepatotoxicity by Interacting with Isoflavones

Engineering
Geniposide, the principal active iridoid glucoside ingredient in Fructus gardeniae used in numerous traditional Chinese clinical prescriptions, has been shown to cause herbal hepatotoxicity because of its glycone metabolite genipin.
Wen Yang, Wen Zhang, Xinhui Huang, Shuwen Geng, Yujia Zhai, Yuetong Jiang, Tian Tian, Yuye Gao, Jing He, Taohong Huang, Yunxia Li, Wenjing Zhang, Jun Wen, Jian-lin Wu, Guangji Wang, Tingting Zhou   +15 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps-0

, 2011
Rage linkage HCA dendrogram (vertical axis represents Euclidean distance). Second row: resulting K-means prototype vectors (vertical axis: conditions). Third row: bar plot of the corresponding cluster sizes (vertical axis: cluster size).
Peter Meinicke (18061), Cornelia Göbel (94444), Alexander Kaever (94442), Petr Karlovsky (72651), Kirstin Feussner (94443), Thomas Lingner (93705), Ivo Feussner (94445), Burkhard Morgenstern (7977)   +7 more
core   +1 more source

1H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture [PDF]

, 2013
We report an NMR based approach to determine the metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture by investigating the extracellular cell culture media and intracellular metabolome of CHOK1 and CHO-S cells ...
Mark J. Howard (443860), C Mark Smales, Masterton, Rosalyn J., Howard, Mark J., Jane L. Wagstaff (469296), Jane F. Povey (469298), Wagstaff, Jane L., Smales, Christopher Mark, C. Mark Smales (128831), Povey, Jane F., Jane L Wagstaff, Rosalyn J Masterton, Rosalyn J. Masterton (469297), Mark J Howard, Jane F Povey   +14 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Investigation of the Antioxidant Activity and Phenolic Compounds of Andricus quercustozae Gall and Host Plant (Quercus infectoria)

, 2020
Andricus quercustozae (Bosc, 1792) is a cynipid gall wasp, which induces gall on oaks (Quercus spp.). It is known that both cynipid galls and oaks are used in traditional medicine.
Özge KILINÇARSLAN AKSOY, Aksoy, Ö.K., Mammadov, R., Aksoy, Özge Kılıçarslan, Mammadov, Ramazan, Yusuf KATILMIŞ, Ramazan MAMMADOV, Katılmış, Yusuf, Musa AZMAZ, Azmaz, M., Azmaz, Musa, Katılmış, Y.   +11 more
core   +1 more source

Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model

Pharmacological Research
The transition from preclinical to clinical drug development is critically impeded by interspecies disparities, which limit the predictive validity of preclinical efficacy for human outcomes.
Xiaojing Liu, Jing He, Lixun Cui, Ying Ye, Miaomiao Luo, Hongzhan Xu, Yujia Zhai, Zixin Zhao, Taohong Huang, Yunxia Li, Jian-lin Wu, Jun Wen, Yong Wang, Tingting Zhou   +13 more
doaj   +1 more source