Results 111 to 120 of about 535,210 (299)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

Unlock the Walnut: How a Pectin‐Rich Suture Tissue and Moisture‐Driven Crack Formation Induce Shell Splitting and Facilitate Seed Germination

open access: yesAdvanced Functional Materials, EarlyView.
Walnut seeds are enclosed in a remarkably strong shell made of sclerenchyma, separated by a pectin‐rich suture tissue. Different cell shapes and chemical composition of this tissue point to an opening mechanism, which is triggered by cyclic humidity changes.
Sebastian J. Antreich   +3 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li   +9 more
wiley   +1 more source

Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

open access: yesAdvanced Healthcare Materials, EarlyView.
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo   +8 more
wiley   +1 more source

A Global View of Metabolites

open access: yesChemistry & Biology, 2006
Fungi are rich sources of medically useful, as well as toxic, secondary metabolites. In this issue of Chemistry & Biology, Bok et al. show that, in Aspergillus nidulans, microarray analysis and manipulation of a global regulator can identify novel metabolite genes.
openaire   +3 more sources

High‐Throughput Encapsulation of Stem Cells: Characterizing Dynamic Culture Variability With a Millifluidic Approach

open access: yesAdvanced Healthcare Materials, EarlyView.
A high throughput millifluidic encapsulation platform is engineered and standardized. The system's output allows the monitoring of cell expansion in strong dynamic conditions. High polymer crosslinking leads to higher cell proliferation and lower cell growth on microgel's surface.
Oscar Fabian García‐Aponte   +6 more
wiley   +1 more source

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