Pre-Analytical Factors that Affect Metabolite Stability in Human Urine, Plasma, and Serum: A Review
Metabolites, 2019 Metabolomics provides a comprehensive assessment of numerous small molecules in biological samples. As it integrates the effects of exogenous exposures, endogenous metabolism, and genetic variation, metabolomics is well-suited for studies examining ...
Victoria L. Stevens +3 more
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Supplementary Figure Legend from Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate <i>in vivo</i> [PDF]
, 2023 Maria L.H. Vlaming +6 more
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Advanced Functional Materials, EarlyView.This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian +5 more
wiley +1 more source
Arthritis Research & TherapyBackground Osteoarthritis (OA) is the leading cause of pain worldwide. However, clinical discordance between pain and cartilage damage presents challenges in determining the mechanisms of OA pain, thus creating a need for well-controlled models that ...
Priscilla M. Tjandra +10 more
doaj +1 more source
Frontiers in Plant ScienceIntroductionCasuarina equisetifolia is a common protective forest in coastal areas. However, artificial C. equisetifolia forests cannot self-renew, mainly due to the accumulation of allelochemicals.
Ying Wang +4 more
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Supplementary Data from Exposure–Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing [PDF]
, 2023 Olivia Campagne +8 more
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, 2012 Abstract This chapter provides an overview of recent research on the effects of genotype fruit development and growing conditions on the synthesis and concentrations of the following metabolites in pepper (Capsicum spp.): antioxidants, carotenoids, phenolic compounds, capsaicinoids, flavonoids and vitamin C.
Frary, Amy, Frary, Anne
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Deciphering Small Molecule Diffusion Parameters Across Light Responsive Polymersome Membranes
Advanced Functional Materials, EarlyView.Light‐responsive polymersomes bearing donor–acceptor Stenhouse adducts (DASAs) enable programmable control over small‐molecule transport across synthetic membranes. By systematically varying DASA density, an optimal functionalization regime is identified that maximizes light‐gated permeability.
Farzina Matubbar +7 more
wiley +1 more source
The interaction between gut microbiota and hibernation in mammals
Frontiers in MicrobiologyHibernation, an evolved survival trait among animals, enables them to endure frigid temperatures and food scarcity during the winter months, and it is a widespread phenomenon observed in mammals.
Peng Gao, Wenjing Shen, Tingbei Bo
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Pathway Tools version 23.0: Integrated Software for Pathway/Genome Informatics and Systems Biology
, 2019 Pathway Tools is a bioinformatics software environment with a broad set of capabilities. The software provides genome-informatics tools such as a genome browser, sequence alignments, a genome-variant analyzer, and comparative-genomics operations.
Billington, Richard +9 more
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