Results 11 to 20 of about 527,693 (324)

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer’s disease based on multi-platform metabolomics analyses

open access: yesFrontiers in Pharmacology, 2022
Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat Alzheimer’s disease (AD). However, the effect and its molecular mechanism are not elucidated clear.
Hui Wang   +6 more
doaj   +1 more source

Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma

open access: yesMetabolites, 2023
The untargeted approach to mass spectrometry-based metabolomics has a wide potential to investigate health and disease states, identify new biomarkers for diseases, and elucidate metabolic pathways.
Michał Kaczmarek   +4 more
doaj   +1 more source

New Insights into Molecular Mechanisms Mediating Adaptation to Exercise; A Review Focusing on Mitochondrial Biogenesis, Mitochondrial Function, Mitophagy and Autophagy

open access: yesCells, 2021
Exercise itself is fundamental for good health, and when practiced regularly confers a myriad of metabolic benefits in a range of tissues. These benefits are mediated by a range of adaptive responses in a coordinated, multi-organ manner.
Fiona Louise Roberts, Greg Robert Markby
doaj   +1 more source

Zhi-Zi-Chi Decoction Reverses Depressive Behaviors in CUMS Rats by Reducing Oxidative Stress Injury Via Regulating GSH/GSSG Pathway

open access: yesFrontiers in Pharmacology, 2022
Depression is one of the main diseases that lead to disability and loss of ability to work. As a traditional Chinese medicine, Zhi-zi-chi decoction is utilized to regulate and improve depression.
Yin Zhang   +18 more
doaj   +1 more source

Saliva metabolome alterations after acute stress

open access: yesScientific Reports, 2022
Major stress has systemic effects on the body that can have adverse consequences for physical and mental health. However, the molecular basis of these damaging effects remains incompletely understood.
Liat Morgan   +11 more
doaj   +1 more source

Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells

open access: yesFrontiers in Pharmacology, 2021
Zhi-zi-chi Decoction (ZZCD), composed of Fructus Gardeniae (Zhizi in Chinese, ZZ in brief) and Semen sojae praeparatum (Dandouchi in Chinese, DDC in brief), has been used as a drug therapy for depression for thousands of years in China.
Yin Zhang   +9 more
doaj   +1 more source

Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultra-high magnetic field [PDF]

open access: yesMagnetic Resonance in Medicine 91 (2024) 4-18, 2023
A new sequence for single-voxel diffusion-weighted 1H MRS (DWS), named DW-SPECIAL, is proposed to improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites. It combines the semi-adiabatic SPECIAL sequence with a stimulated echo (STE) diffusion block.
arxiv   +1 more source

Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies

open access: yesMolecules, 2017
Chlorin e6-C15-monomethyl ester (CMME) is a novel photosensitizer, which is synthetized from the degradation products of silkworm excrement. Preclinical studies on the promising photosensitizer CMME are necessary to determine its therapeutic efficacy and
Xiuxiu Li   +5 more
doaj   +1 more source

Enantioselective Separation of Mirtazapine and Its Metabolites by Capillary Electrophoresis with Acetonitrile Field-Amplified Sample Stacking and Its Application

open access: yesMolecules, 2014
A simple, rapid and sensitive chiral capillary zone electrophoresis coupled with acetonitrile-field-amplified sample stacking method was developed that allows the simultaneous enantioselective separation of the mirtazapine, N-demethylmirtazapine, 8 ...
Jun Wen   +6 more
doaj   +1 more source

Global architecture of metabolite distributions across species and its formation mechanisms [PDF]

open access: yesBiosystems 100, 8 (2010), 2011
Living organisms produce metabolites of many types via their metabolisms. Especially, flavonoids, a kind of secondary metabolites, of plant species are interesting examples. Since plant species are believed to have specific flavonoids with respect to diverse environment, elucidation of design principles of metabolite distributions across plant species ...
arxiv   +1 more source

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