Results 21 to 30 of about 1,686,019 (401)

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source

SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information

Nature Methods, 2019
Mass spectrometry is a predominant experimental technique in metabolomics and related fields, but metabolite structural elucidation remains highly challenging.
Kai Dührkop, Markus Fleischauer, M. Ludwig, A. Aksenov, A. Melnik, Marvin Meusel, P. Dorrestein, Juho Rousu, Sebastian Böcker   +8 more
semanticscholar   +1 more source

Enantioselective Separation of Mirtazapine and Its Metabolites by Capillary Electrophoresis with Acetonitrile Field-Amplified Sample Stacking and Its Application

Molecules, 2014
A simple, rapid and sensitive chiral capillary zone electrophoresis coupled with acetonitrile-field-amplified sample stacking method was developed that allows the simultaneous enantioselective separation of the mirtazapine, N-demethylmirtazapine, 8 ...
Jun Wen, Wen-Ting Zhang, Wei-Qun Cao, Ji Li, Fang-Yuan Gao, Nan Yang, Guo-Rong Fan   +6 more
doaj   +1 more source

MetAssign: probabilistic annotation of metabolites from LC–MS data using a Bayesian clustering approach [PDF]

, 2014
Motivation: The use of liquid chromatography coupled to mass spectrometry (LC–MS) has enabled the high-throughput profiling of the metabolite composition of biological samples.
Breitling, Rainer, Burgess, Karl E.V., Daly, Rónán, Jankevics, Andris, Rogers, Simon, Wandy, Joe   +5 more
core   +2 more sources

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood.
E. Mills, D. Ryan, H. Prag, D. Dikovskaya, D. Menon, Z. Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, M. Higgins, E. Hams, John Szpyt, M. Runtsch, M. King, J. McGouran, R. Fischer, B. Kessler, A. F. Mcgettrick, M. Hughes, R. Carroll, Lee M. Booty, Elena V. Knatko, P. Meakin, M. Ashford, Louise K Modis, Gino Brunori, D. Sévin, P. Fallon, S. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, C. Frezza, A. Dinkova-Kostova, R. Hartley, M. Murphy, L. O’Neill   +34 more
semanticscholar   +1 more source

Using cell membrane chromatography and HPLC-TOF/MS method for in vivo study of active components from roots of Aconitum carmichaeli

Journal of Pharmaceutical Analysis, 2011
An offline two-dimensional system combining a rat cardiac muscle cell membrane chromatography time-of-flight mass spectrometry (CMC-TOF/MS) with a high Performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) was established for ...
Yan Cao, Xiao-Fei Chen, Di-Ya Lü, Xin Dong, Guo-Qing Zhang, Yi-Feng Chai   +5 more
doaj   +1 more source

Making It Last: Storage Time and Temperature Have Differential Impacts on Metabolite Profiles of Airway Samples from Cystic Fibrosis Patients. [PDF]

, 2017
Metabolites of human or microbial origin have the potential to be important biomarkers of the disease state in cystic fibrosis (CF). Clinical sample collection and storage conditions may impact metabolite abundances with clinical relevance.
John J. LiPuma, Katrine Whiteson, Lisa Carmody, Peter J. Turnbaugh, Stephen Wandro, Tara Gallagher   +5 more
core   +3 more sources

Metabolite Profiles and the Risk of Developing Diabetes

Nature Medicine, 2011
Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes.
Thomas J. Wang, M. Larson, R. Vasan, Susan Cheng, E. Rhee, Elizabeth L. McCabe, G. Lewis, C. Fox, P. Jacques, C. Fernandez, C. O’Donnell, S. Carr, V. Mootha, J. Florez, Amanda L. Souza, O. Melander, C. Clish, R. Gerszten   +17 more
semanticscholar   +1 more source

Human metabolite detection by surface-enhanced Raman spectroscopy

Materials Today Bio, 2022
Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine.
Yao Lu, Li Lin, Jian Ye
semanticscholar   +1 more source

Antimicrobial and Antioxidant Potential of Endophytic Fungi Isolated from Ethnomedicinal Plants of Western Ghats, Karnataka

Journal of Pure and Applied Microbiology, 2017
A total of 79 endophytic fungal isolates were obtained from four wild medicinal plants-Tinospora cordifolia (Willd.) Hook.f and Thomson (Menispermaceae), Piper nigrum L., Piper longum L.
Fazilath Uzma , Srinivas Chowdappa
doaj   +1 more source