Results 11 to 20 of about 1,686,019 (401)
An exercise-inducible metabolite that suppresses feeding and obesity
Nature, 2022 Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases1–5. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear6.
Veronica L. Li +28 more
semanticscholar +1 more source
The gut metabolite indole-3 propionate promotes nerve regeneration and repair
Nature, 2022 The regenerative potential of mammalian peripheral nervous system neurons after injury is critically limited by their slow axonal regenerative rate1. Regenerative ability is influenced by both injury-dependent and injury-independent mechanisms2.
Elisabeth Serger +18 more
semanticscholar +1 more source
bioRxiv, 2022 Liquid chromatography - mass spectrometry (LC-MS) based untargeted metabolomics allows to measure both known and unknown metabolites in the metabolome. However, unknown metabolite annotation is a grand challenge in untargeted metabolomics.
Zhiwei Zhou +5 more
semanticscholar +1 more source
Agronomy, 2021 Plant secondary metabolites (SMs) play important roles in plant survival and in creating ecological connections between other species. In addition to providing a variety of valuable natural products, secondary metabolites help protect plants against ...
R. Jan +4 more
semanticscholar +1 more source
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Nucleic Acids Res., 2019 Secondary metabolites produced by bacteria and fungi are an important source of antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad applications in identifying and characterizing new compounds as well as in ...
K. Blin +7 more
semanticscholar +1 more source
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
Cell, 2020 Summary Using untargeted metabolomics (n=1,162 subjects), the plasma metabolite (m/z=265.1188) phenylacetylglutamine (PAGln) was discovered, and then shown in an independent cohort (n=4,000 subjects) to be associated with cardiovascular disease (CVD) and
I. Nemet +18 more
semanticscholar +1 more source
Molecular Metabolism, 2023 Objective: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively.
Jacob Emil Petersen +9 more
doaj +1 more source
Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection [PDF]
, 2005 We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their agyclone structures, 2-methyl-3-(3-3-carboxymethylpropyl)-1,4-naphthoquinone (5C-side-chain metabolite) and 2-methyl-3-(5-carboxy-3-
Edwards, C +5 more
core +1 more source
Understanding and Classifying Metabolite Space and Metabolite-Likeness
PLoS ONE, 2011 While the entirety of 'Chemical Space' is huge (and assumed to contain between 10(63) and 10(200) 'small molecules'), distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolites, defined as 'naturally occurring' products of an
Peironcely, Miguel J.E. +4 more
openaire +6 more sources
Sleep Drives Metabolite Clearance from the Adult Brain
Science, 2013 Taking Out the Trash The purpose of sleep remains mysterious. Using state-of-the-art in vivo two-photon imaging to directly compare two arousal states in the same mouse, Xie et al. (p.
Lulu Xie +12 more
semanticscholar +1 more source