Results 21 to 30 of about 527,693 (324)

Antimicrobial and Antioxidant Potential of Endophytic Fungi Isolated from Ethnomedicinal Plants of Western Ghats, Karnataka

open access: yesJournal of Pure and Applied Microbiology, 2017
A total of 79 endophytic fungal isolates were obtained from four wild medicinal plants-Tinospora cordifolia (Willd.) Hook.f and Thomson (Menispermaceae), Piper nigrum L., Piper longum L.
Fazilath Uzma , Srinivas Chowdappa
doaj   +1 more source

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

open access: yesMolecules, 2020
Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) are the two known bile acid (BA) sensitive receptors and are expressed in the intestine and liver as well as in extra-enterohepatic tissues.
Samuel A. J. Trammell   +4 more
doaj   +1 more source

Predicting pathways for old and new metabolites through clustering [PDF]

open access: yesarXiv, 2022
The diverse metabolic pathways are fundamental to all living organisms, as they harvest energy, synthesize biomass components, produce molecules to interact with the microenvironment, and neutralize toxins. While discovery of new metabolites and pathways continues, the prediction of pathways for new metabolites can be challenging.
arxiv  

Antimicrobial Activity and Phytochemical Analysis of Endophytic Fungal Extracts Isolated from Ethno-Pharmaceutical Plant Rauwolfia tetraphylla L.

open access: yesJournal of Pure and Applied Microbiology, 2018
Endophytes are the mimicking the plant secondary metabolites as well as vast number chemical synthesizers inside plants and also have been extensively investigated for their endophytic microbial complement. Different parts of Rauwolfia tetraphylla L were
Ramesha Alurappa, Srinivas Chowdappa
doaj   +1 more source

The advantage of leakage of essential metabolites and resultant symbiosis of diverse species [PDF]

open access: yesPhys. Rev. Lett. 124, 048101 (2020), 2018
Microbial communities display extreme diversity. A variety of strains or species coexist even when limited by a single resource. It has been argued that metabolite secretion creates new niches and facilitates such diversity. Nonetheless, it is still a controversial topic why cells secrete even essential metabolites so often; in fact, even under ...
arxiv   +1 more source

Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk

open access: yesFrontiers in Endocrinology, 2021
Cardiometabolic disease affects the majority of individuals worldwide. The metabolite α-aminoadipic acid (2-AAA) was identified as a biomarker of Type 2 Diabetes (T2D). However, the mechanisms underlying this association remain unknown. DHTKD1, a central
Chuan Wang   +2 more
doaj   +1 more source

High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates

open access: yesMolecules, 2017
Sodium Danshensu (sodium d-(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza, exhibits potent relaxation of the coronary artery and anticoagulation effection.
Jingjing Jiang   +6 more
doaj   +1 more source

Screening of immune cell activators from Astragali Radix using a comprehensive two-dimensional NK-92MI cell membrane chromatography/C18 column/time-of-flight mass spectrometry system

open access: yesJournal of Pharmaceutical Analysis, 2022
Astragali Radix (AR) is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer (NK) cells.
Xinyi Chai   +10 more
doaj  

In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

open access: yesFrontiers in Pharmacology, 2022
Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative “superbugs”, including MDR K ...
Wan Yean Chung   +5 more
doaj   +1 more source

Metabolite mediated modeling of microbial community dynamics captures emergent behavior more effectively than species-species modeling [PDF]

open access: yes, 2019
Personalized models of the gut microbiome are valuable for disease prevention and treatment. For this, one requires a mathematical model that predicts microbial community composition and the emergent behavior of microbial communities. We seek a modeling strategy that can capture emergent behavior when built from sets of universal individual ...
arxiv   +1 more source

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