Results 21 to 30 of about 985,469 (331)
Acta Pharmaceutica Sinica B, 2022 Cell membrane affinity chromatography has been widely applied in membrane protein (MP)-targeted drug screening and interaction analysis. However, in current methods, the MP sources are derived from cell lines or recombinant protein expression, which are ...
Yanqiu Gu +13 more
doaj +1 more source
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
, 2016 Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering.
Bar-Even, Arren +5 more
core +6 more sources
Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence. [PDF]
, 2014 Human diets differ from those of non-human primates. Among few obvious differences, humans consume more meat than most non-human primates and regularly cook their food.
Blekhman, Ran +5 more
core +2 more sources
Journal of Pain and Symptom Management, 2005 The metabolism of opioids closely relates to their chemical structure. Opioids are subject to O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I metabolites. By glucuronidation or sulfatation, phase-II metabolites are formed.
openaire +2 more sources
Journal of Pure and Applied Microbiology, 2018 Endophytes are the mimicking the plant secondary metabolites as well as vast number chemical synthesizers inside plants and also have been extensively investigated for their endophytic microbial complement. Different parts of Rauwolfia tetraphylla L were
Ramesha Alurappa, Srinivas Chowdappa
doaj +1 more source
Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]
, 2018 Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent +2 more
core +1 more source
Journal of Pharmaceutical Analysis, 2011 A comparison of the volatile compounds in Rhizomes Curcumae (Ezhu) and Radix Curcumae (Yujin) was undertaken using gas chromatographyâmass spectrometry (GCâMS).
Di-Ya Lü +7 more
doaj +1 more source
Molecules, 2020 Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) are the two known bile acid (BA) sensitive receptors and are expressed in the intestine and liver as well as in extra-enterohepatic tissues.
Samuel A. J. Trammell +4 more
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Research Note: Changes in chicken egg yolk metabolome during its formation
Poultry Science, 2023 : The process of egg yolk formation involves the transport and uptake of a large number of small molecule metabolites. A qualitative and relative quantitative analysis of metabolites in the 3 formation periods of egg yolk was performed by a liquid ...
Yi Wang +5 more
doaj +1 more source