Results 191 to 200 of about 1,006,561 (307)

PMconv: How to Compare Proteomes and Metabolomes? [PDF]

Int J Mol Sci
Kozlova A, Kliuchnikova A, Gordeeva A, Lisitsa A, Ponomarenko E, Ilgisonis E.   +5 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Exploring the metabolic characteristics of fresh-cut sweet potatoes at different storage times based on untargeted metabolomics. [PDF]

Food Chem X
Wan X, Wang X, Chen M, Cui L, Xiao Q.
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Discovery of a preliminary urinary metabolite panel for Parkinson's disease: a pilot study using paired patient-spouse samples and machine learning consensus. [PDF]

Front Neurol
Chen QQ, Gou DH, Huang JY, Mo ZH, Guan XY, Xu JN.   +5 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.

Nat Prod Rep
Kulkarni AS, Carrara GMP, Jin J, Laro J, Peramuna T, McCall LI, Garg N.   +6 more
europepmc   +1 more source

Metabolomic profiles of dietary exposure associated with frailty in older adults: A systematic review. [PDF]

J Frailty Aging
El Sherbiny S, Puzankova E, Martínez-Huélamo M, Garcia-Giralt N, Carnicero Carreño JA, Rodriguez Mañas L, Serra Rexach JA, García García FJ, Nogués X, Abizanda Soler P, Andrés-Lacueva C, Rabassa M.   +11 more
europepmc   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Chlebek C, Bussberg V, Narain NR, Kiebish MA, Tseng YH, Rosen CJ, Lynes MD.   +6 more
europepmc   +1 more source