Results 201 to 210 of about 1,007,992 (307)

Discovery of a preliminary urinary metabolite panel for Parkinson's disease: a pilot study using paired patient-spouse samples and machine learning consensus. [PDF]

Front Neurol
Chen QQ, Gou DH, Huang JY, Mo ZH, Guan XY, Xu JN.   +5 more
europepmc   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.

Nat Prod Rep
Kulkarni AS, Carrara GMP, Jin J, Laro J, Peramuna T, McCall LI, Garg N.   +6 more
europepmc   +1 more source

Metabolomic profiles of dietary exposure associated with frailty in older adults: A systematic review. [PDF]

J Frailty Aging
El Sherbiny S, Puzankova E, Martínez-Huélamo M, Garcia-Giralt N, Carnicero Carreño JA, Rodriguez Mañas L, Serra Rexach JA, García García FJ, Nogués X, Abizanda Soler P, Andrés-Lacueva C, Rabassa M.   +11 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Chlebek C, Bussberg V, Narain NR, Kiebish MA, Tseng YH, Rosen CJ, Lynes MD.   +6 more
europepmc   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Comprehensive Metabolomic Profiling of Skin Lesions from Psoriasis Patients Reveals Disease Signatures. [PDF]

Int J Biol Sci
Zhu P, Wang Y, Sun J, Cai J, Chen Z, Cui L, Song X, Wang Y, Yu Z, Gong Y, Yu Q, Shi Y.   +11 more
europepmc   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Characterization of multi-stage metabolic alterations in hepatitis B virus-related acute-on-chronic liver failure using high-coverage metabolomics. [PDF]

Metabolomics
Zhang Z, Jiang H, Zhang G, Chen D, Su X, Li L, Li L.   +6 more
europepmc   +1 more source