Results 351 to 360 of about 2,167,847 (388)

Bioactivity of dietary polyphenols: The role of metabolites

Critical reviews in food science and nutrition, 2020
A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral
S. Luca, I. Macovei, Alexandra Bujor, A. Miron, K. Skalicka‐Woźniak, A. C. Aprotosoaie, A. Trifan   +6 more
semanticscholar   +1 more source

Metabolites of Phencyclidine

Clinical Toxicology, 1976
The results of the animal experiment demonstrate that oxidative hydroxylation is the major mode of metabolism of phencyclidine. It is evident that this process takes place in all three rings of the molecule. Hydroxylation of the piperidyl moiety probably also accounts for the formation of the N-dealkylated metabolites.
L K, Wong, K, Biemann
openaire   +2 more sources

Bioactive acetylenic metabolites

Phytomedicine, 2013
This article focuses on anticancer, and other biological activities of acetylenic metabolites obtained from plants and fungi. Acetylenic compounds belong to a class of molecules containing triple bond(s). Naturally occurring acetylenics are of particular interest since many of them display important biological activities and possess antitumor ...
Dmitry V, Kuklev, Abraham J, Domb, Valery M, Dembitsky   +2 more
openaire   +2 more sources

Mitochondrial metabolite transport

Essays in Biochemistry, 2010
The flux of a variety of metabolites, nucleotides and coenzymes across the inner membrane of mitochondria is catalysed by a nuclear-coded superfamily of secondary transport proteins called MCs (mitochondrial carriers). The importance of MCs is demonstrated by their wide distribution in all eukaryotes, their role in numerous metabolic pathways and cell ...
PALMIERI F, PIERRI, CIRO LEONARDO
openaire   +2 more sources

Metabolite regulates differentiation

Science, 2018
Compartmentalized NAD + metabolism regulates transcription to control adipogenesis
Sophie, Trefely, Kathryn E, Wellen
openaire   +2 more sources

Which Metabolites Circulate?

Drug Metabolism and Disposition, 2013
Characterization of the circulating metabolites for a new chemical entity in humans is essential for safety assessment, an understanding of their contributions to pharmacologic activities, and their potential involvement in drug-drug interactions. This review examines the abundance of metabolites relative to the total parent drug [metabolite-to-parent (
Cho-Ming, Loi, Dennis A, Smith, Deepak, Dalvie   +2 more
openaire   +2 more sources

Metabolites, enzymes, and metabolite analogues

1973
The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 2. The present chapter deals in greater detail with one cause of high specificity, namely a close resemblance between (a) the normal substrate (or coenzyme) of an ...
openaire   +1 more source

Metabolites of Mitragynine

Journal of Pharmaceutical Sciences, 1974
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E, Zarembo, B, Douglas, J, Valenta, J A, Weisbach   +3 more
openaire   +2 more sources

Metabolites as signalling molecules

Nature reviews. Molecular cell biology, 2023
S. A. Baker, J. Rutter
semanticscholar   +1 more source

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Nature reviews: Gastroenterology & hepatology, 2020
A. Lavelle, H. Sokol
semanticscholar   +1 more source