Results 171 to 180 of about 1,743 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Inclusão de ácidos graxos de cadeia curta em diferentes níveis de cálcio na dieta de frangos de corte Inclusion of short chain fatty acids and different calcium levels in diets for broilers

Ciência Rural, 2010
Noventa e seis frangos de corte, machos, de linhagem Cobb e de 21 aos 31 dias de idade foram alimentados com a inclusão de ácidos graxos de cadeia curta (AGCC) e diferentes níveis de cálcio. Foram determinados o balanço de cálcio (Ca) e de fósforo (P), a
Maitê de Moraes Vieira, Alexandre de Mello Kessler, Andréa Machado Leal Ribeiro   +2 more
doaj  

Effects of dietary energy concentration, NSP concentration and particle sizes of NSP on digesta passage rate and gut development in laying hens [PDF]

Er is een lineair verband gevonden tussen de hoeveelheid NSP die een leghen dagelijks opneemt en de verblijfstijd van het voer in de krop en klier-/spiermaag. Dit verband was meer uitgesproken bij grove in plaats van bij fijne vezels.
Hartog, L.A., den, Krimpen, M.M., van, Kwakkel, R.P., Peet-Schwering, C.M.C., van der, Verstegen, M.W.A.   +4 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Assessments of productive performance, eggshell quality, excreta moisture, and incubation traits of laying breeder hens fed a proprietary blend of Quillaja and Yucca. [PDF]

Front Vet Sci, 2022
Souza OF, Adams CB, Agilar JC, Biselo V, Mello RO, Gomez LG, Bonaspetti S, Stefanello C.   +7 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Improving water productivity, reducing poverty and enhancing equity in mixed crop-livestock systems in the Indo-Gangetic Basin: CPWF project report 68 [PDF]

Farming systems / Mixed farming / Water productivity / Feed production / Livestock / Energy consumption / Gender / Poverty / River basins / Case studies / India / Indo-Gangetic Basin / West Bengal / Haryana / Uttar ...
Acharya, N. Sreedhar, Blummel, M., Clement, Floriane, Dey, A., Haileslassie, A., Ishaq, Saba, Khan, M. A., Mit, R., Radha, A. Venkata, Samad, Madar, Shindey, D. N.   +10 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Multi-carbohydrase complex supplementation improves crude protein and energy utilization of corn-soybean-based diets with or without HP-DDGS in growing pigs. [PDF]

Transl Anim Sci
da Motta SAB, de Araújo WAG, Fagundes NS, Toscan AB, Miranda AL, Gutierrez Riaño A, Pereira GTS, Neves RR, Ribeiro GDS, Silva BAN.   +9 more
europepmc   +1 more source