Results 281 to 290 of about 114,008 (316)
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2019
The human metabolome is the cumulative product of ingested metabolites and those produced by the body and its microbiota. Together these metabolites can dynamically report on the health and disease state of an individual, as well as their response to drug treatments and other external perturbations.
David P, Marciano, Michael P, Snyder
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The human metabolome is the cumulative product of ingested metabolites and those produced by the body and its microbiota. Together these metabolites can dynamically report on the health and disease state of an individual, as well as their response to drug treatments and other external perturbations.
David P, Marciano, Michael P, Snyder
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2014
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry that offers the best prediction of the phenotype and the nature of a disease. Mass spectrometry now allows thousands of metabolites to be quantitated.
Francis G, Bowling, Mervyn, Thomas
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Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry that offers the best prediction of the phenotype and the nature of a disease. Mass spectrometry now allows thousands of metabolites to be quantitated.
Francis G, Bowling, Mervyn, Thomas
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Clinica Chimica Acta, 2012
Metabolomics is a powerful technique for the discovery of novel biomarkers and elucidation of biochemical pathways to improve diagnosis, prognosis and therapy. An advantage of this approach is its ability to assess global metabolic profiles to enhance pathologic characterization.
Aihua, Zhang +3 more
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Metabolomics is a powerful technique for the discovery of novel biomarkers and elucidation of biochemical pathways to improve diagnosis, prognosis and therapy. An advantage of this approach is its ability to assess global metabolic profiles to enhance pathologic characterization.
Aihua, Zhang +3 more
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Understanding the metabolome – challenges for metabolomics
Nutrition Bulletin, 2008SummaryMetabolomics is a comprehensive method for metabolite assessment, measuring the overall metabolic signature of biological samples. This approach opens up many possibilities in areas such as new biomarker discovery and hypothesis generation. The application of metabolomics is growing rapidly but many challenges must first be addressed before it ...
M. C. Walsh +3 more
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Journal of Hypertension, 2014
Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension.
Nikolic, Sonja B. +3 more
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Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension.
Nikolic, Sonja B. +3 more
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2009
Metabolomics, one of the "omic" sciences in systems biology, is the global assessment and validation of endogenous small-molecule biochemicals (metabolites) within a biologic system. Initially, putative quantitative metabolic biomarkers for cancer detection and/or assessment of efficacy of anticancer treatment are usually discovered in a preclinical ...
Natalie J, Serkova, Kristine, Glunde
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Metabolomics, one of the "omic" sciences in systems biology, is the global assessment and validation of endogenous small-molecule biochemicals (metabolites) within a biologic system. Initially, putative quantitative metabolic biomarkers for cancer detection and/or assessment of efficacy of anticancer treatment are usually discovered in a preclinical ...
Natalie J, Serkova, Kristine, Glunde
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Clinica Chimica Acta, 2014
Characterization of metabolic changes is key to early detection, treatment, and understanding molecular mechanisms of diabetes. Diabetes represents one of the most important global health problems. Approximately 90% of diabetics have type 2 diabetes. Identification of effective screening markers is critical for early treatment and intervention that can
Ai-hua, Zhang +4 more
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Characterization of metabolic changes is key to early detection, treatment, and understanding molecular mechanisms of diabetes. Diabetes represents one of the most important global health problems. Approximately 90% of diabetics have type 2 diabetes. Identification of effective screening markers is critical for early treatment and intervention that can
Ai-hua, Zhang +4 more
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2020
Metabolomics addresses a comprehensive view of metabolites depicting biological and nonenzymatic processes. The metabolomics requests integrative application of epidemiology, analytics, and bioinformatics and provides information on specific metabolic signatures in health and disease.
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Metabolomics addresses a comprehensive view of metabolites depicting biological and nonenzymatic processes. The metabolomics requests integrative application of epidemiology, analytics, and bioinformatics and provides information on specific metabolic signatures in health and disease.
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2004
Metabolism is the ensemble of chemical transformations carried out in living tissue; operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (M r .
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Metabolism is the ensemble of chemical transformations carried out in living tissue; operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (M r .
openaire +1 more source