Results 131 to 140 of about 297,367 (349)

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Nature Methods, 2021
S. Alseekh, A. Aharoni, Y. Brotman, K. Contrepois, J. D’Auria, Jan Ewald, Jennifer C Ewald, P. Fraser, Patrick Giavalisco, R. Hall, Matthias Heinemann, H. Link, Jie Luo, S. Neumann, J. Nielsen, Leonardo Perez de Souza, K. Saito, U. Sauer, F. Schroeder, S. Schuster, G. Siuzdak, A. Skirycz, L. Sumner, M. Snyder, Huiru Tang, Takayuki Tohge, Yulan Wang, Weiwei Wen, Si Wu, Guowang Xu, Nicola Zamboni, A. Fernie   +31 more
semanticscholar   +1 more source

Characterizing the Flavor Precursors and Liberation Mechanisms of Various Dry-Aging Methods in Cull Beef Loins Using Metabolomics and Microbiome Approaches [PDF]

, 2022
Derico Setyabrata, K. R. Vierck, Tessa R. Sheets, Jerrad F. Legako, Bruce R. Cooper, Timothy A. Johnson, Yuan H. Brad Kim   +6 more
openalex   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops [PDF]

, 2018
Bastien Christ, Tomáš Pluskal, Sylvain Aubry, Jing‐Ke Weng   +3 more
openalex   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Antihypertensive Therapy by ACEI/ARB Is Associated With Intestinal Flora Alterations and Metabolomic Profiles in Hypertensive Patients

, 2022
Ying Dong, Pan Wang, Jie Jiao, Xinchun Yang, Mulei Chen, Jing Li   +5 more
openalex   +1 more source

Metabolomics of Photosynthetically Active Tissues in White Grapes: Effects of Light Microclimate and Stress Mitigation Strategies [PDF]

, 2021
Andreia Garrido, Jasper Engel, Roland Mumm, Artur Conde, Ana Cunha, Ric C. H. de Vos   +5 more
openalex   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Targeted Metabolomics Connects Thioredoxin-interacting Protein (TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle [PDF]

, 2014
Karen L. DeBalsi, Kari E. Wong, Timothy R. Koves, Dorothy H. Slentz, Sarah E. Seiler, April Wittmann, Olga Ilkayeva, Robert D. Stevens, Christopher G. R. Perry, Daniel S. Lark, Simon T. Hui, Luke I. Szweda, P. Darrell Neufer, Deborah M. Muoio   +13 more
openalex   +1 more source

Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles [PDF]

, 2022
Adina‐Elena Segneanu, Gabriela Vlase, Alexandra Teodora Lukinich-Gruia, Dumitru-Daniel Herea, Ioan Grozescu   +4 more
openalex   +1 more source