Results 161 to 170 of about 393,797 (377)

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Myeloid Progenitor Transformation Assay

Bio-Protocol, 2017
Numerous oncogenes have been identified to cause leukemia. For example, chromosomal translocation generates various fusion genes of the mixed-lineage leukemia (MLL) gene and a partner gene in leukemia, whose gene products transform primary myeloid ...
Hiroshi Okuda, Akihiko Yokoyama
doaj   +1 more source

Personal Metabolomics as a Next Generation Nutritional Assessment [PDF]

, 2003
J. Bruce German, Matthew-Alan Roberts, Steven M. Watkins   +2 more
openalex   +1 more source

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

Advanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin, Runlan Yan, Junqi Zhu, Bei Li, Yinyan Zhong, Shuang Han, Huiting Wang, Jianmin Wu, Zhao Chen, Yuyue Jiang, Aiwu Pan, Xuqing Huang, Xiaoming Chen, Pingya Zhu, Sheng Cao, Wenhua Liang, Peng Ye, Yue Gao   +17 more
wiley   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
wiley   +1 more source

In vivo Leukemogenesis Model Using Retrovirus Transduction

Bio-Protocol, 2017
Various genetic alterations such as chromosomal translocation cause leukemia. For examples, gene rearrangements of the mixed-lineage leukemia (MLL) gene generate MLL fusion genes, whose products are potent oncogenic drivers in acute leukemia.
Hiroshi Okuda, Akihiko Yokoyama
doaj   +1 more source

Metabolomics: Pandora's Box or Aladdin's Cave? [PDF]

, 2003
Kevin M. Brindle
openalex   +1 more source

Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu, Aidan E. Gilchrist, Patrik K. Johansson, Yuan Guan, Jaydon D. Deras, Yu‐Chung Liu, Sofia Ceva, Michelle S. Huang, Renato S. Navarro, Annika Enejder, Gary Peltz, Sarah C. Heilshorn   +11 more
wiley   +1 more source

Biomarkers of glucose-insulin homeostasis and incident type 2 diabetes and cardiovascular disease: results from the Vitamin D and Omega-3 trial

Cardiovascular Diabetology
Background Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent.
Frank Qian, Yanjun Guo, Chunying Li, Yanyan Liu, Heike Luttmann-Gibson, Natalya Gomelskaya, Olga V. Demler, Nancy R. Cook, I-Min Lee, Julie E. Buring, Julia Larsen, Jennifer Boring, Michael J. McPhaul, JoAnn E. Manson, Aruna D. Pradhan, Samia Mora   +15 more
doaj   +1 more source

Mass spectrometry-based metabolomics in microbiome investigations

Nature Reviews Microbiology, 2021
A. Bauermeister, H. Mannochio-Russo, Letícia V. Costa-Lotufo, Alan K. Jarmusch, P. Dorrestein   +4 more
semanticscholar   +1 more source