Results 211 to 220 of about 186,058 (269)

Reviving Data Potential─The Reanalysis-Driven Metabolomics Data Repository MB-POST. [PDF]

Anal Chem
Takahashi Y, Yoshizawa AC, Kiuchi T, Hayasaka R, Torigoe T, Takahashi M, Oka T, Matsuzawa Y, Ogawa M, Izumi Y, Tsugawa H, Hirayama A, Matsuda F, Okuda S.   +13 more
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Metabolomics-Based Identification of α-Glucosidase Inhibitors from <i>Pometia pinnata</i> Stem Bark Using LC-HRMS and Molecular Docking. [PDF]

Molecules
Husniati H, Elya B, Hanafi M, Lotulung PDN, Hermawan F, Rifaldi R, Rosa D, Khatib A.   +7 more
europepmc   +1 more source

Mass Spectrometry-Based N‑Glycomics of Total Serum and IgG Provides Complementary Insights into Multiple Sclerosis

ACS Omega
Dalma Dojcsák, Marco Bladergroen, Wenjun Wang, Oleg A. Mayboroda, Csaba Váradi, Tamás Pongrácz, Manfred Wuhrer   +6 more
doaj   +1 more source

Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young adults. [PDF]

Physiol Rep
Graham ZA, Pathak KV, Garcia-Mansfield K, Lavin KM, Torres AR, McAdam JS, Broderick T, Pirrotte P, Bamman MM.   +8 more
europepmc   +1 more source

Food characterization in the omics era: current advances, analytical approaches, and future perspectives. [PDF]

Front Nutr
Ibrahim MS, Azeem W, Sakandar HA, Curran D, Yousaf AA, Zabetakis I.   +5 more
europepmc   +1 more source