Results 131 to 140 of about 478,976 (349)

A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat [PDF]

arXiv, 2020
Background: In patients with psychotic disorders, sleep spindles are reduced, supporting the hypothesis that the thalamus and glutamate receptors play a crucial etio-pathophysiological role, whose underlying mechanisms remain unknown. We hypothesized that a reduced function of NMDA receptors is involved in the spindle deficit observed in schizophrenia.
arxiv  

Robust gamma oscillations in networks of inhibitory Hippocampal interneurons [PDF]

arXiv, 1999
Recent experiments suggest that inhibitory networks of interneurons can synchronize the neuronal discharge in in vitro hippocampal slices. Subsequent theoretical work has shown that strong synchronization by mutual inhibition is only moderately robust against neuronal heterogeneities in the current drive, provided by activation of metabotropic ...
arxiv  

Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice

Journal of Neuroscience, 2016
Altered function of the Gq-coupled, Group 1 metabotropic glutamate receptors, specifically mGlu5, is implicated in multiple mouse models of autism and intellectual disability.
Weirui Guo, G. Molinaro, K. A. Collins, S. Hays, R. Paylor, P. Worley, K. Szumlinski, K. Huber   +7 more
semanticscholar   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, EarlyView.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract

World Journal of Gastroenterology, 2017
Metabotropic glutamate receptor subtype 5 (mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other mGluR subtypes, mGluR5s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane ...
FERRIGNO, ANDREA, BERARDO, CLARISSA ANGELA IRIS, DI PASQUA, LAURA GIUSEPPINA, SICILIANO, VERONICA, RICHELMI, PLINIO, VAIRETTI, MARIAPIA   +5 more
openaire   +5 more sources

[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells [PDF]

, 1996
The effect of glutamate receptor agonists on the intracellular free calcium concentration ([Ca2+]i), measured with Indo-1, was studied in populations of cultured chick embryonic retina cells.
Carvalho, Arsélio P., Duarte, Carlos B., Santos, Paulo F.   +2 more
core   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Acute Ketamine Infusion in Rat Does Not Affect In Vivo [C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

Molecular Imaging, 2018
Detecting changes in metabotropic glutamate receptor 5 (mGluR5) availability through molecular imaging with the positron emission tomography (PET) tracer [ 11 C]ABP688 is valuable for studying dysfunctional glutamate transmission associated with ...
Lauren Kosten, Jeroen Verhaeghe, Leonie wyffels, Sigrid Stroobants, Steven Staelens   +4 more
doaj   +1 more source