Results 131 to 140 of about 55,471 (274)

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]

, 2009
Víctor Briz, Mireia Galofré, Cristina Suñol   +2 more
openalex   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons

Frontiers in Cellular Neuroscience, 2014
Neuronal activity results in long lasting changes in synaptic structure and function by regulating mRNA translation in dendrites. These activity dependent events yield the synthesis of proteins known to be important for synaptic modifications and diverse
Christopher eHeise, Fabrizio eGardoni, Lorenza eCulotta, Monica eDiLuca, Chiara eVerpelli, Carlo eSala, Carlo eSala   +6 more
doaj   +1 more source

Metabotropic Glutamate Receptor 5 Antagonism with Fenobam [PDF]

, 2011
Michael C. Montana, Beth A. Conrardy, Laura F. Cavallone, Benedict J. Kolber, Lesley K. Rao, Suellen Greco, Robert W. Gereau   +6 more
openalex   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators [PDF]

, 2020
Víctor Fernández‐Dueñas, Mingcheng Qian, Josep Argerich, Carolina Maria Medeiros do Amaral, Martijn Risseeuw, Serge Van Calenbergh, Francisco Ciruela   +6 more
openalex   +1 more source

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex

Human Brain Mapping, Volume 46, Issue 18, 15 December 2025.
We leveraged in vivo 7T GluCEST MRI and normative PET receptor maps to examine the spatial covariation between cortical glutamate levels and receptor expression. GluCEST signal showed positive spatial associations with NMDA and GABAA, but not mGluR5. These findings enhance our understanding of GluCEST and glutamate‐receptor dynamics across the cortex ...
Maggie K. Pecsok, Golia Shafiei, Ally Atkins, Monica E. Calkins, Ruben C. Gur, Ravi Prakash Reddy Nanga, Ravinder Reddy, Melanie A. Matyi, Jacquelyn Stifelman, Heather Robinson, Erica B. Baller, Russell T. Shinohara, Kosha Ruparel, Kristin A. Linn, Daniel H. Wolf, Theodore D. Satterthwaite, Corey T. McMillan, David Roalf   +17 more
wiley   +1 more source

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome

Journal of Experimental Pharmacology, 2013
Mary Sourial, Connie Cheng, Laurie C Doering Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Abstract: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading ...
Sourial M, Cheng C, Doering LC
doaj  

FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism.
Qing Song, Wen-Li Gou, Yu-Liang Zou
doaj   +1 more source