Results 241 to 250 of about 55,471 (274)

The role of metabotropic glutamate receptor 5 in developmental lead neurotoxicity

Toxicology Letters, 2009
A complete explanation of the mechanisms of lead-induced developmental neurotoxicity remains unknown. The glutamate receptor is one of the most important targets of lead. More recently, metabotropic glutamate receptor 5 (mGluR5) has been shown to have a functional relationship with learning and memory.
Jian, Xu, Chong-huai, Yan, Bo, Yang, Han-fang, Xie, Xiang-yu, Zou, Le, Zhong, Yu, Gao, Ying, Tian, Xiao-ming, Shen   +8 more
openaire   +2 more sources

The Role of Metabotropic Glutamate Receptor 5 in Learning and Memory Processes

Drug News & Perspectives, 2005
Metabotropic glutamate receptor 5 (mGluR5), a subtype in the group I mGluRs, couples to phospholipase C through Gq protein. Stimulation of mGluR5 leads to the release of calcium from intracellular stores and protein kinase C activation. In addition, links to different ion channels and other signaling mechanisms have also been revealed.
Simonyi, Agnes, Schachtman, Todd, Christoffersen, Gert Rene Juul   +2 more
openaire   +2 more sources

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Clinical Science, 2018
Metabotropic glutamate receptors belong to class C G-protein-coupled receptors and consist of eight subtypes that are ubiquitously expressed throughout the central nervous system. In recent years, the metabotropic glutamate receptor subtype 5 (mGlu5) has emerged as a promising target for a broad range of psychiatric and neurological disorders.
Phuc N.H. Trinh, Lauren T. May, Katie Leach, Karen J. Gregory   +3 more
openaire   +2 more sources

Discovery of novel modulators of metabotropic glutamate receptor subtype-5

Bioorganic & Medicinal Chemistry, 2004
A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored.
Bowei, Wang, Jean Michel, Vernier, Sara, Rao, Janice, Chung, Jeffery J, Anderson, Jesse D, Brodkin, Xiaohui, Jiang, Michael F, Gardner, Xiaoqing, Yang, Benito, Munoz   +9 more
openaire   +2 more sources

AstroWars: the return of the astrocytic metabotropic glutamate receptor 5

The Journal of Physiology
AbstractIn the brain, astrocytes express glutamate receptors to detect glutamatergic signalling at synapses. Numerous studies have been conducted to characterize the types and levels of receptor expression, their physiological properties and functional roles. The metabotropic glutamate receptor 5 (mGluR5) is particularly noteworthy.
José Duarte Dias, João Filipe Viana, Luís Samuel Alves, Alexandra Veiga, Bruna Matos, João Luís Machado, João Filipe Oliveira   +6 more
openaire   +2 more sources

Constitutive internalization and recycling of metabotropic glutamate receptor 5 (mGluR5)

Biochemical and Biophysical Research Communications, 2012
Ligand-dependent and ligand-independent endocytic trafficking of G-protein coupled receptors (GPCRs) is critical for accurate receptor-mediated signaling and its regulation. Metabotropic glutamate receptor 5 (mGluR5) is a GPCR that plays a crucial role in circuit formation in the brain and also in various forms of synaptic plasticity including learning
Rishi Raj, Trivedi, Samarjit, Bhattacharyya   +1 more
openaire   +2 more sources

Coincident modulation of adenosine receptor and metabotropic glutamate receptor 5

2021
Neurodegenerative disorders, such as Alzheimer’s disease are among the leading causes of death and disease burden. Therefore, new therapeutic targets are needed to treat both symptoms and disease progression. Glutamate and adenosine receptors are key proteins modulating brain cells’ activity.
openaire   +1 more source

Design and Synthesis of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Santosh S, Kulkarni, Barbara, Nightingale, Christina M, Dersch, Richard B, Rothman, Amy Hauck, Newman   +4 more
openaire   +2 more sources

Differential effects of protein phosphatases in the recycling of metabotropic glutamate receptor 5

Neuroscience, 2015
The major excitatory neurotransmitter Glutamate acts on both ionotropic and metabotropic glutamate receptors (mGluRs) in the central nervous system. mGluR5, a member of the group I mGluR family is widely expressed throughout the brain and plays important roles in a variety of neuronal processes including various forms of synaptic plasticity.
P K, Mahato, S, Pandey, S, Bhattacharyya
openaire   +2 more sources

Metabotropic Glutamate Receptor 5: A Potential Molecular Switch and Beyond

Biological Psychiatry, 2022
Zhaodi Liu, Hui Ma, Shuai Long, Yong Zhang   +3 more
openaire   +2 more sources