GABAB Receptors Mediate Intracellular Calcium Release in Astrocytes of the Prefrontal Cortex
European Journal of Neuroscience, Volume 62, Issue 1, July 2025.We took advantage of GLAST‐promoter driven GCaMP6s expression in astrocytes to study Ca2+ signaling in astrocytes of the young adult prefrontal cortex in response to GABA with confocal Ca2+ imaging. The results show that GABA induces Ca2+ signaling via the stimulation of the metabotropic GABAB receptor in astrocytes.
Jennifer Bostel +2 more
wiley +1 more source
The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors. [PDF]
Molecules, 2023 Gates CA +3 more
europepmc +1 more source
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
, 1993 Ivan Jeanne Weiler, William T. Greenough
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Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: A possible factor regulating synaptic protein synthesis [PDF]
, 1998 Frank Angenstein +2 more
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European Journal of Neuroscience, Volume 62, Issue 1, July 2025.Using DNA methylation data collected on adults prenatally exposed to the Chinese famine of 1959–1961, this study reports the altered epigenetic regulation in genes of the glutamate synapse pathway in association with early‐life adversity. Our analysis revealed an overall pattern of reduced DNA methylation of the pathway genes that is more pronounced in
Zhen Tan +4 more
wiley +1 more source
Does Corticothalamic Feedback Control Cortical Velocity Tuning? [PDF]
, 2001 The thalamus is the major gate to the cortex and its contribution to cortical receptive field properties is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic ...
Hillenbrand, Dr. Ulrich +1 more
core
Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid. [PDF]
Psychopharmacology (Berl), 2023 D'Antoni S +9 more
europepmc +1 more source
Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus [PDF]
, 1996 Domenico E. Pellegrini‐Giampietro +2 more
openalex +1 more source
Estrogenic regulation of hippocampal inhibitory system across lifespan
Journal of Neuroendocrinology, Volume 37, Issue 7, July 2025.Abstract Estrogens produced in peripheral tissues and locally in the brain are potent neuromodulators. The function of the hippocampus, a brain region essential for episodic memory and spatial navigation, relies on the activity of ensembles of excitatory neurons whose activity is temporally and spatially coordinated by a wide diversity of inhibitory ...
Pablo Méndez +2 more
wiley +1 more source
Attenuation of Stimulated Accumbal Dopamine Release by NMDA Is Mediated through Metabotropic Glutamate Receptors. [PDF]
ACS Chem Neurosci, 2023 Spencer FSE +4 more
europepmc +1 more source