Results 91 to 100 of about 2,336,805 (315)

Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex. [PDF]

Front Neuroanat, 2022
Woo E, Datta D, Arnsten AFT.
europepmc   +1 more source

Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells [PDF]

, 2013
Eukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus saturation. Despite numerous differences in the adaptation mechanisms employed by bacteria and eukaryotes, all require energy consumption.
De Palo, Giovanna, Endres, Robert G.
core   +4 more sources

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine [PDF]

, 1993
D G Winder, P. Jeffrey Conn
openalex   +1 more source

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

Journal of Neuroscience, 1997
Neurotransmission in the hippocampus is modulated variously through presynaptic metabotropic glutamate receptors (mGluRs). To establish the precise localization of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies for eight ...
R. Shigemoto, A. Kinoshita, Eiki Wada, S. Nomura, H. Ohishi, M. Takada, P. Flor, A. Neki, Takaaki Abe, S. Nakanishi, N. Mizuno   +10 more
semanticscholar   +1 more source

Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su, Huan Qin, Jie Shen, Hao An, Yu Cao   +4 more
wiley   +1 more source

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat [PDF]

, 1992
Ryuichi Shigemoto, Shigetada Nakanishi, Noboru Mizuno   +2 more
openalex   +1 more source

Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Wu et al. studied why certain brain areas are more connected than others. They found that areas with similar protein patterns tend to work together more closely. Additionally, they found when one area is affected such as in brain tumours, other areas with similar patterns especially contralateral regions might help.
Jinsong Wu, Zixian Wang, Fengjiao Li, Shuolei Bu, Lianglong Sun, Chen Zheng, Zhixin Bai, Luhao Yang, Fangyuan Gong, Jiali Chen, Yien Huang, Wanjing Li, Guoquan Yan, Weiwei Xian, Jiaxuan Yang, Shuai Wu, Kemin Zhu, Wenke Fan, Qiong Liu, Guomin Zhou, Gong‐Hong Wei, Wensheng Li, Jing Yan, Jingliang Cheng, Russell G. Snell, Maurice A. Curtis, Tianye Jia, Binke Yuan, Yong He, Weijiang Zhang, Linya You   +30 more
wiley   +1 more source

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4 [PDF]

, 1993
Yasuto Tanabe, Akihiro Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru Mizuno, Shigetada Nakanishi   +5 more
openalex   +1 more source

The mRNA Translation Inhibitor Vioprolide A Prevents Inflammatory Pain‐Like Behaviour With Limited Action on Already Established Pain‐Like Behaviour in Mice

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Background Accumulating evidence indicates that pharmacological inhibition of the translational machinery is a therapeutic strategy for various diseases. However, whether inhibitors of mRNA translation might be suitable for pain therapy remains poorly understood. Here, we tested the potential analgesic effects of the natural product vioprolide
Patrick Engel, Tilman Gross, Gesine Wack, Rekia Sinderwald, Luisa Burgers, Robert Fürst, Achim Schmidtko   +6 more
wiley   +1 more source