Results 91 to 100 of about 2,328,855 (357)

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway [PDF]

, 2013
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine
Ahn, Al-Hayani, Alberati-Giani, Alexander, Alexander, Alvarez, Angot, Baez, Banerjee, Beal, Breton, Broadstock, Brown, Brown, C.M. Forrest, Cai, Charytoniuk, Chess, Chess, Chess, Chiarugi, Clark, Colonnese, Copeland, Corbo, Couillard-Despres, Cozzi, Cuppini, D. Jerusalinsky, Dave, Dellovade, Dikranian, Dobbing, Dobelis, Drian, du Bois, Dykens, E. Kornisiuk, English, Erhardt, Ernst, Fagiolini, Fatemi, Fazio, Forrest, Forsythe, Friocourt, Gleeson, Gobaille, Goncalves, Guidetti, Guillemin, Guillemin, Gurdon, Harris, Harvey, Heng, Higgins, Higgins, Hilmas, Hiramatsu, Hoffman, Holtze, Hor, Hornig, Huang, Hynes, Ikonomidou, Iwasato, Jin, K. McNair, Kappeler, Kemp, Kerjan, L.G. Darlington, Larson, Leung, M. Pisar, M. Snitcofsky, Martel, Meyer, Miller, Mok, Munn, Myers, N. Gonzalez, Nacher, Nathan, Neale, Neher, Nilsson, Niswender, O.S. Khalil, Okuda, Otis, Ozaki, O’Kane, Palma, Parish, Pena, Perkins, Pfaffl, Pocivavsek, Potter, Prajerova, Rajan, Ramakers, Ramoa, Rodgers, Rosenmund, Röver, Saito, Saviane, Schwarcz, Schwarcz, Shin, Simon, Sims, Spassky, Stone, Stone, Stone, Stone, Stone, Stringer, T.W. Stone, Taleb, Tang, Traiffort, Traiffort, Traiffort, Traynelis, Udin, Ultanir, Vaillant, Vincent, Waldeck, Walker, Wang, Wang, Wierońska, Wu, Xiong, Zucker, Zuckerman   +144 more
core   +2 more sources

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

Molecular determinants of acute kidney injury [PDF]

, 2015
BACKGROUND: Acute kidney injury (AKI) is a condition that leads to a rapid deterioration of renal function associated with impairment to maintain electrolyte and acid balance, and, if left untreated, ultimately irreversible kidney damage and renal ...
Human, Christin, Husi, Holger
core   +2 more sources

The Metabotropic Receptor mGluR6 May Signal Through Go, But Not Phosphodiesterase, in Retinal Bipolar Cells

Journal of Neuroscience, 1999
Bipolar cells are retinal interneurons that receive synaptic input from photoreceptors. Glutamate, the photoreceptor transmitter, hyperpolarizes On bipolar cells by closing nonselective cation channels, an effect mediated by the metabotropic receptor ...
S. Nawy
semanticscholar   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, EarlyView.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Shedding Light on Metabotropic Glutamate Receptors [PDF]

Cell Chemical Biology, 2016
In this issue of Cell Chemical Biology, the elegant manuscript by Rovira et al. (2016) describes a negative allosteric modulator (NAM) of mGlu4 metabotropic glutamate receptors with in vivo activity. This compound is rapidly and reversibly inactivated by light and represents a powerful pharmacological tool for the study of mGlu4 receptors in their ...
openaire   +3 more sources

Metabotropic actions of kainate receptors in the CNS [PDF]

Journal of Neurochemistry, 2007
AbstractKainate receptors (KARs), together with NMDA and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors (AMPA), are typically described as ionotropic glutamate receptors. Although ionotropic functions for KARs are beginning to be characterized in multiple brain regions, both, in the pre‐ and post‐synaptic compartments of the synapse, there ...
Antonio Rodríguez-Moreno, Talvinder S. Sihra   +1 more
openaire   +3 more sources