Results 1 to 10 of about 126,867 (267)
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors [PDF]
Journal of Experimental Medicine, 2018 Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade.
C. Kaittanis +16 more
semanticscholar +5 more sources
Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Lumeng J. Yu +3 more
semanticscholar +3 more sources
Metabotropic Glutamate Receptors [PDF]
Journal of Biological Chemistry, 2015 Background: C. elegans encodes three metabotropic glutamate receptors: mgl-1, mgl-2, and mgl-3. Results: mgl-1 and mgl-3, but not mgl-2, modulate activity in the neural circuit underlying feeding behavior.
J. Dillon +8 more
semanticscholar +2 more sources
The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
doaj +2 more sources
Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan +3 more
doaj +3 more sources
Role of Metabotropic Glutamate Receptors in Neurological Disorders
Frontiers in Molecular Neuroscience, 2019 Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi +3 more
doaj +2 more sources
Researching glutamate – induced cytotoxicity in different cell lines: a comparative/, collective analysis/study [PDF]
Frontiers in Cellular Neuroscience, 2015 Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis +3 more
doaj +3 more sources
Optical Control of Metabotropic Glutamate Receptors [PDF]
Nature Neuroscience, 2013 G protein–coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to
Joshua Levitz +11 more
semanticscholar +4 more sources
Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus [PDF]
BiomedicinesBackground/Objectives: The neurotransmitter glycine is involved in several physiological and pathological conditions in the Central Nervous System. Different biological structures, including glycine receptors and transporters, are under study as targets ...
Luca Raiteri +3 more
doaj +2 more sources
Membranes, 2022 Metabotropic glutamate receptors (mGluRs) are membrane receptors that play a central role in the modulation of synaptic transmission and neuronal excitability and whose dysregulation is implicated in diverse neurological disorders.
Brice Miller +3 more
doaj +1 more source