Results 1 to 10 of about 100,227 (220)

Metabotropic glutamate receptors in cancer [PDF]

Neuropharmacology, 2017
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Lumeng J, Yu, Brian A, Wall, Janet, Wangari-Talbot, Suzie, Chen   +3 more
openaire   +3 more sources

Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia. [PDF]

Mol Pharmacol, 2022
Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia patients has led to efforts to target various components of glutamatergic signaling as potential new approaches for schizophrenia.
Dogra S, Conn PJ.
europepmc   +2 more sources

Metabotropic Glutamate Receptors [PDF]

Journal of Biological Chemistry, 2015
Background: C. elegans encodes three metabotropic glutamate receptors: mgl-1, mgl-2, and mgl-3. Results: mgl-1 and mgl-3, but not mgl-2, modulate activity in the neural circuit underlying feeding behavior.
James Dillon, Christopher J. Franks, Caitriona Murray, Richard J. Edwards, Fernando Calahorro, Takeshi Ishihara, Isao Katsura, Lindy Holden-Dye, Vincent O'Connor   +8 more
openaire   +2 more sources

Kinetic fingerprinting of metabotropic glutamate receptors [PDF]

Communications Biology, 2023
FRET and confocal patch-clamp fluorometry in oocytes is used to analyze glutamateinduced conformational changes and dimerization of mGluR 1-8 homo- and heterodimers.
Taulant Kukaj, Christian Sattler, Thomas Zimmer, Ralf Schmauder, Klaus Benndorf   +4 more
doaj   +2 more sources

The Role of Glutamate Receptors in Epilepsy

Biomedicines, 2023
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang   +3 more
doaj   +2 more sources

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +3 more sources

Role of Metabotropic Glutamate Receptors in Neurological Disorders

Frontiers in Molecular Neuroscience, 2019
Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Salvatore Cuzzocrea   +3 more
doaj   +2 more sources

Optical control of metabotropic glutamate receptors [PDF]

Nature Neuroscience, 2013
G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Levitz, J.; Pantoja, C.; Gaub, B; Janovjak, H.; Reiner, A.; Hoagland, A.; Schoppik, D.; Kane, B.; Stawski, P.; Schier, A. F.; Trauner, D.*; Isacoff, E. Y.*   +12 more
openaire   +4 more sources

Sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus [PDF]

Brain and Neuroscience Advances
The modulation of synaptic efficacy by group I metabotropic glutamate receptors is dysregulated in several neurodevelopmental and neurodegenerative disorders impacting cognitive function.
Liam T. Ralph, John Georgiou, Graham L. Collingridge, Patrick Tidball   +3 more
doaj   +2 more sources

Microtransplantation of Postmortem Native Synaptic mGluRs Receptors into Xenopus Oocytes for Their Functional Analysis

Membranes, 2022
Metabotropic glutamate receptors (mGluRs) are membrane receptors that play a central role in the modulation of synaptic transmission and neuronal excitability and whose dysregulation is implicated in diverse neurological disorders.
Brice Miller, Naomi Moreno, Berenice A. Gutierrez, Agenor Limon   +3 more
doaj   +1 more source