Results 11 to 20 of about 100,227 (220)

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors

Journal of Experimental Medicine, 2018
Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade.
C. Kaittanis, C. Andreou, H. Hieronymus, Ninghui Mao, C. Foss, M. Eiber, G. Weirich, Palak Panchal, A. Gopalan, J. Zurita, S. Achilefu, G. Chiosis, V. Ponomarev, M. Schwaiger, B. Carver, M. Pomper, J. Grimm   +16 more
semanticscholar   +3 more sources

Metabotropic glutamate receptors: physiology, pharmacology, and disease.

Annual Review of Pharmacology and Toxicology, 2010
C. Niswender, P. Conn
semanticscholar   +3 more sources

Metabotropic glutamate receptor trafficking [PDF]

Molecular and Cellular Neuroscience, 2018
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh, Kai Chang, Katherine W. Roche   +2 more
openaire   +2 more sources

Expression of GABAAα1, GABAB1, and mGluR2 receptors in the lateral geniculate body of male neonates born to diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Diabetes during gestation is one of the most common pregnancy complications and has adverse effects on offspring, including a negative impact on the offspring’s central nervous system (CNS).
Nasim Alipour, Somaye Fallahnezhad, Javad Bagheri, Hamideh Babaloo, Fatemeh Tahmasebi, Ghasem Sazegar, Hossein Haghir   +6 more
doaj   +1 more source

Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

Frontiers in Neurology, 2020
Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate ...
Allison R. Peterson, Devin K. Binder
doaj   +1 more source

Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. [PDF]

PLoS ONE, 2011
Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic calcium concentration at hippocampal synapses, resulting in various types of changes in synaptic strength.
Renaud Greget, Fabien Pernot, Jean-Marie C Bouteiller, Viviane Ghaderi, Sushmita Allam, Anne Florence Keller, Nicolas Ambert, Arnaud Legendre, Merdan Sarmis, Olivier Haeberle, Michel Faupel, Serge Bischoff, Theodore W Berger, Michel Baudry   +13 more
doaj   +1 more source

Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors

Cell Reports, 2020
SUMMARY The eight metabotropic glutamate receptors (mGluRs) serve critical modulatory roles throughout the nervous system. The molecular diversity of mGluRs is thought to be further expanded by the formation of heterodimers, but the co-expression of ...
Joon Lee, H. Munguba, Vanessa A. Gutzeit, Melanie Kristt, J. Dittman, Joshua Levitz   +5 more
semanticscholar   +1 more source

The Hippocampus Is the Place to Be: Opioid Receptors and LTP

Cell Reports, 2019
Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson, John Georgiou, Patrick Tidball, Graham L. Collingridge   +3 more
doaj   +1 more source

Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2

eLife, 2020
Metabotropic glutamate receptors (mGluRs) play an important role in synaptic plasticity and memory and are largely classified based on amino acid sequence homology and pharmacological properties.
Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumar   +7 more
doaj   +1 more source

Metabotropic glutamate receptors: from the workbench to the bedside.

Neuropharmacology, 2011
F. Nicoletti, J. Bockaert, G. Collingridge, P. Conn, F. Ferraguti, D. Schoepp, J. Wroblewski, J. Pin   +7 more
semanticscholar   +3 more sources