Results 101 to 110 of about 2,328,855 (357)

Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2

eLife, 2020
Metabotropic glutamate receptors (mGluRs) play an important role in synaptic plasticity and memory and are largely classified based on amino acid sequence homology and pharmacological properties.
Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumar   +7 more
doaj   +1 more source

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Membrane Topology of a Metabotropic Glutamate Receptor [PDF]

Journal of Biological Chemistry, 2003
The metabotropic glutamate receptors (mGluRs) have been predicted to have a classical seven transmembrane domain structure similar to that seen for members of the G-protein-coupled receptor (GPCR) superfamily. However, the mGluRs (and other members of the family C GPCRs) show no sequence homology to the rhodopsin-like GPCRs, for which this seven ...
Ruchir D. Shah, D. J. Brasier, Stephen F. Heinemann, Gautam Bhave, Kathi S. Glauner, Robert W. Gereau, Brian M. Nadin, Farzana Karim   +7 more
openaire   +3 more sources

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. [PDF]

, 2012
Protein synthesis is highly regulated throughout nervous system development, plasticity and regeneration. However, tracking the distributions of specific new protein species has not been possible in living neurons or at the ultrastructural level ...
Butko, Margaret T, Ellisman, Mark H, Geng, Yang, Jeon, Noo Li, Kim, Hyung Joon, Lin, Michael Z, Mackey, Mason R, Shu, Xiaokun, Tsien, Roger Y, Yang, Jin   +9 more
core   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats

Journal of Pharmacological Sciences, 2010
This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H1 receptor antagonist–induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal
Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei   +2 more
doaj  

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]

, 2019
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Abba, Martín Carlos, Aldaz, Claudio Marcelo, Attaluri, Sahithi, Hattiangady, Bharathi, Hussain, Tabish, Kil, Hyunsuk, Kodali, Maheedhar, Lee, Jaeho, Shen, Jianjun, Shetty, Ashok K., Shuai, Bing, Takata, Yoko   +11 more
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Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue‐based and cell‐based assays

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira, Anna Maria Gomes, Ana Carolina Zetehaku, Taissa Ferrari Marinho, Fabio Fieni Toso, Caio César Diniz Disserol, Mariana Braatz Krueger, Mara Lúcia Schmitz Ferreira Santos, Aline Freire Borges Juliano, Tércio Luz Barbosa, Letícia Januzi de Almeida Rocha, Fernando Tenório Gameleira, Renata Barbosa Paolilo, Vanessa Daccach, João Pedro Izidoro Gomes, Katia Lin, Adaucto Wanderley da Nóbrega Jr., Emily Lima Marmentini, Eduardo Ferracioli Fusão, Anderson de Cuffa, Georgia Lelis Aranha Tavares, Ronaldo Maciel Dias, Sabrina Stephanie Lana Diniz, Fábio Siquineli, Pedro Braga‐Neto, Paulo Ribeiro Nobrega, Lorena Pitombeira Sanders, Fernanda Martins Maia Carvalho, Renata Brasileiro Reis Pereira, Eduardo Sousa de Melo, Adélia Maria de Miranda Henriques‐Souza, Clecio de Oliveira Godeiro Jr., Omar Gurrola Arambula, Filipe Nolasco de Souza e Silva, Karla Oliveira Couto, Dayane Danieli, Katia Werneck Seitz, Alessandra Dellavance, Verena Endmayr, Romana Höftberger, Luis Eduardo Coelho Andrade, Luis Otavio Caboclo, Livia Almeida Dutra   +42 more
wiley   +1 more source

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources