Results 111 to 120 of about 2,328,855 (357)

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect

Brain Sciences, 2019
Allosteric modulators of metabotropic glutamate 5 receptors (mGlu5 receptors) have been identified as a promising treatment to independently alleviate both negative affective states and ethanol-seeking and intake.
Chelsea R. Kasten, Eleanor B. Holmgren, Tiffany A. Wills   +2 more
doaj   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

G-protein activation by a metabotropic glutamate receptor

Nature, 2021
A. B. Seven, X. Barros-Álvarez, Marine de Lapeyrière, M. Papasergi-Scott, M. J. Robertson, Chensong Zhang, Robert M Nwokonko, Yang Gao, J. Meyerowitz, J. Rocher, Dominik W. Schelshorn, B. Kobilka, J. M. Mathiesen, G. Skiniotis   +13 more
semanticscholar   +1 more source

Emerging roles for integrated stress response signaling in homeostasis

The FEBS Journal, EarlyView.
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan   +2 more
wiley   +1 more source

Activation of G protein‐coupled parathyroid hormone receptors in rat incisor odontoblasts promotes mineralization via cyclic adenosine monophosphate, not Ca2+ signalling: In vitro study

International Endodontic Journal, EarlyView.
Abstract Aim Parathyroid hormone (PTH) and its Gαs‐coupled receptors, PTH receptor, mediate odontoblast differentiation; however, the detailed intracellular adenylyl cyclase‐mediated signalling pathway mediated by the PTH–PTH receptor axis remains to be elucidated. Therefore, we measured the intracellular levels of cyclic adenosine monophosphate (cAMP)
Natsuki Saito, Takehito Ouchi, Maki Kimura, Ryuya Kurashima, Yoshiyuki Shibukawa   +4 more
wiley   +1 more source

The Drosophila DmGluRA is required for social interaction and memory

Frontiers in Pharmacology, 2013
Metabotropic glutamate receptors (mGluRs) have well established roles in cognition andsocial behavior in mammals. Whether or not these roles have been conserved throughoutevolution from invertebrate species is less clear.
Brian P. Schoenfeld, Brian P. Schoenfeld, Richard J. Choi, Richard J. Choi, Catherine H. Choi, Catherine H. Choi, Catherine H. Choi, Catherine H. Choi, Allison M. Terlizzi, Paul eHinchey, Maria eKollaros, Neal J. Ferrick, Eric H. Koenigsberg, David eFerreiro, David A. Leibelt, Steve J. Siegel, Aaron J. Bell, Aaron J. Bell, Thomas V. McDonald, Thomas A. Jongens, Sean M.J. McBride, Sean M.J. McBride, Sean M.J. McBride   +22 more
doaj   +1 more source

Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation [PDF]

, 2016
The serine protease subtilisin induces a form of long-term depression (LTD) which is accompanied by a reduced expression of the axo-dendritic guidance molecule Unco-ordinated-5C (Unc-5C).
Darlington, L. Gail, Forrest, Caroline M., Stone, Trevor W.   +2 more
core   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Metabotropic glutamate receptor agonists for schizophrenia [PDF]

British Journal of Psychiatry, 2008
SummaryA drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.
openaire   +2 more sources