Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, Volume 12, Issue 29, August 7, 2025.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract Diabetic retinopathy (DR) and Alzheimer's disease (AD) are progressive neurodegenerative disorders affecting the eye and the brain, respectively. Despite targeting different organs, they share common molecular mechanisms. A central process connecting these conditions is the unfolded protein response (UPR), which maintains protein homeostasis ...
Adrián G. Palacios +2 more
wiley +1 more source
The effects of (RS)‐α‐cyclopropyl‐4‐phosphonophenylglycine ((RS)‐CPPG), a potent and selective metabotropic glutamate receptor antagonist [PDF]
, 1996 Nick J. Toms +4 more
openalex +1 more source
The Role of Peripheral N‐Methyl‐D‐Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review
European Journal of Pain, Volume 29, Issue 7, August 2025.ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Ryusuke Tanaka +3 more
wiley +1 more source
, 2004 Self-referencing H+-selective microelectrodes were used to measure extracellular H+ fluxes from horizontal cells isolated from the skate retina. A standing H+ flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions
Birnbaum, Andrea D. +6 more
core +2 more sources
Stimulatory effects of the putative metabotropic glutamate receptor antagonist L‐AP3 on phosphoinositide turnover in neonatal rat cerebral cortex [PDF]
, 1996 Rajendra Mistry +3 more
openalex +1 more source
Glia, Volume 73, Issue 8, Page 1642-1659, August 2025.Main Points AQP4ex and OAP‐forming AQP4M23 are expressed in non‐neuronal cells of the olfactory epithelium. AQP4ex‐KO and OAP‐null mice show reduced cell density, including OSNs, and impaired odor responses and behavior, with AQP4ex emerging as key regulator.
Donatella Lobraico +8 more
wiley +1 more source
Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG [PDF]
, 1995 Gernot Riedel, G. Casabona, KG Reymann
openalex +1 more source
Role and Mechanism of Microglia in White Matter Injury Recovery in Ischemic Stroke
Immunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.Many studies have shown that stroke can cause microglia activation, and activated microglia differentiate into different types according to different time and region, and different types of microglia play an important role in the process of white matter recovery.
Yi‐Sha Guo +3 more
wiley +1 more source
Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
core