Exocytosis of Vesicular Zinc Reveals Persistent Depression of Neurotransmitter Release during Metabotropic Glutamate Receptor Long-Term Depression at the Hippocampal CA3–CA1 Synapse [PDF]
, 2006 Jing Qian, Jeffrey L. Noebels
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British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas +2 more
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Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]
, 2009 Víctor Briz +2 more
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Advanced Biology, Volume 9, Issue 12, December 2025.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
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The Interaction of Phospholipase C-{beta}3 with Shank2 Regulates mGluR-mediated Calcium Signal [PDF]
, 2005 Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the
Hwang, Jong-Ik +5 more
core
Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai +9 more
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Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors [PDF]
, 2008 Julie Perroy +6 more
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Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]
, 2018 Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya +8 more
core
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Our group has demonstrated that the subtype 3 metabotropic glutamate receptor (mGlu3R) expressed in astrocytes exerts neuroprotective functions and promotes both non‐amyloidogenic cleavage of APP and Aβ clearance. In turn, we showed that mGlu3R levels progressively decreased with age in the hippocampus of PDAPP‐J20 murine AD model ...
Eugenia Olivera +10 more
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