Results 141 to 150 of about 2,336,805 (315)

Efgartigimod as a Fast‐Acting Add‐On Therapy in Antibody–Mediated Autoimmune Encephalitis

European Journal of Neurology, Volume 32, Issue 8, August 2025.
ABSTRACT Background Autoimmune encephalitis (AE) is a severe neurological disorder that requires effective and safe treatment options. This study aimed to compare the efficacy and safety of intravenous methylprednisolone (IVMP) plus efgartigimod (IPE) versus IVMP alone or IVMP plus immunoglobulin (IPI) as initial treatments for antibody‐mediated AE ...
Zhuajin Bi, Wenzhong Kang, Ruihan Liu, Yan Jiang, Min Chen   +4 more
wiley   +1 more source

Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p. [PDF]

BMC Cancer, 2019
Xiao B, Chen D, Zhou Q, Hang J, Zhang W, Kuang Z, Sun Z, Li L.   +7 more
europepmc   +1 more source

Protein Kinase Cbeta and delta Selectively Phosphorylate Odorant and Metabotropic Glutamate Receptors [PDF]

, 1999
Kathryn F. Medler
openalex   +1 more source

Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl‐L‐Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain

European Journal of Neurology, Volume 32, Issue 8, August 2025.
This monocentric observational study investigates a fixed combination of acetyl‐L‐carnitine, palmitoylethanolamide, and alpha‐lipoic acid in 48 patients with acute low back pain. Over 8 weeks, treatment led to significant reductions in neuropathic pain scores, decreased NSAID consumption, and improvements in quality of life, supporting its potential ...
Mattia Cominacini, Maria Teresa Valenti, Michele Braggio, Alberto Caramori, Ermes Vedovi, Luca Dalle Carbonare   +5 more
wiley   +1 more source

(2S,1’R, 2'R, 3'R)-2-(2,3-Dicarboxycyclopropyl)-glycine (DCG-IV): A type-specific agonist for metabotropic glutamate receptor negatively coupled with adenylate cyclase in rat hippocampus.

, 1994
Mutsumi Maruyama, Mariko Nakazawa
openalex   +1 more source

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Adenosine Receptors in Developing and Adult Mouse Neuromuscular Junctions and Functional Links With Other Metabotropic Receptor Pathways. [PDF]

Front Pharmacol, 2018
Tomàs J, Garcia N, Lanuza MA, Santafé MM, Tomàs M, Nadal L, Hurtado E, Simó-Ollé A, Cilleros-Mañé V, Just-Borràs L.   +9 more
europepmc   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients [PDF]

Proteomics
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Fabrik I, Kupcik R, Fabrikova D, Chvojkova M, Holubova K, Hakenova K, Horak M, Soukup J, Manethova M, Rusina R, Matej R, Ryska A, Soukup O.   +12 more
europepmc   +2 more sources

Anticonvulsant action of metabotropic glutamate receptor agonists in DBA/2 mice.

, 1994
Yoshiko Horikawa, Shigeki Tamura, Norio Inomata, Tomochika Ohno   +3 more
openalex   +1 more source