Axon/Dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy-Terminal Domains [PDF]
Julia Nash Stowell, Ann Marie Craig
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This comprehensive review highlights the role of taste‐active peptides (TAPs) in modulating food taste and promoting health. It explores the taste profile, structure, sources, interactions with taste receptors, bioactivity, and potential applications of TAPs within the food and nutraceutical industries.
Nesma Elhadad, Jianping Wu
wiley +1 more source
Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman+5 more
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Functional Switch from Facilitation to Inhibition in the Control of Glutamate Release by Metabotropic Glutamate Receptors [PDF]
I. Herrero+2 more
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SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling
ABSTRACT Introduction The receptor SorCS2 is involved in the trafficking of membrane receptors and transporters. It has been implicated in brain disorders and has previously been reported to be indispensable for ionotropic glutamatergic neurotransmission in the hippocampus.
Christian Staehr+14 more
wiley +1 more source
The Enteric Neuronal Circuitry: A Key Ignored Player in Nutrient Sensing Along the Gut–Brain Axis
The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. Despite its autonomous ability to execute local functions, its communication with the central nervous system is integral to the maintenance of homeostasis.
Ester Nikolla+4 more
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Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 [PDF]
RW Gereau, P. Jeffrey Conn
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Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty+2 more
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Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 [PDF]
C. Joly+5 more
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GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie+10 more
wiley +1 more source