Results 321 to 330 of about 2,317,385 (378)

Dynamics and modulation of metabotropic glutamate receptors

Current Opinion in Pharmacology, 2015
The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
Jean-Philippe Pin, Philippe Rondard, Philippe Rondard, Philippe Rondard   +3 more
openaire   +4 more sources

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

Journal of Neurophysiology, 2006
Fragile X syndrome (FXS), a form of human mental retardation, is caused by loss of function mutations in the fragile X mental retardation gene (FMR1). The protein product of FMR1, fragile X mental retardation protein (FMRP) is an RNA-binding protein and ...
E. Nosyreva, K. Huber
semanticscholar   +1 more source

Metabotropic receptors for glutamate and GABA in pain

Brain Research Reviews, 2009
Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: ionotropic and metabotropic receptors.
Cyril Goudet, Frédéric Nagy, Frédéric Nagy, Jean-Philippe Pin, Jean-Philippe Pin, Marc Landry, Marc Landry, Valerio Magnaghi, Robert W. Gereau   +8 more
openaire   +3 more sources

Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.

Journal of Neurophysiology, 1994
1. 1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD), a racemic mixture of 1-aminocyclopentane-1S,3R-dicarboxylic acid and 1-aminocyclopentane-1R,3S-dicarboxylic acid, a selective agonist of the metabotropic glutamate receptor, was applied to ...
David J. Linden, M. Smeyne, J. Connor
semanticscholar   +1 more source

The Structures of Metabotropic Glutamate Receptors [PDF]

, 2008
Interest in the structures of the metabotropic glutamate receptors continues to increase for a variety of reasons, including the fact that they are now established drug targets and are linked to a wide spectrum of physiologic processes both within and outside the central nervous system.
Erin M. Rose, David R. Hampson, Jordan E. Antflick   +2 more
openaire   +1 more source

Immunohistochemical visualization of a metabotropic glutamate receptor

NeuroReport, 1993
The immunocytochemical localization of the recently cloned metabotropic glutamate receptor 1 alpha (mGluR1 alpha) was demonstrated with a C-terminus specific antibody in rat cerebellar cortex. This antibody detects a 138-140 kDa major, and a 46 kDa minor band in membrane preparations of rat cortex and cerebellum.
Görcs Tamás Jenő, Penke Botond, Bőti Zsuzsanna, Katarova Zója, Hámori József   +4 more
openaire   +3 more sources

The metabotropic glutamate receptors of the vestibular organs

Hearing Research, 1998
This research sought to test the presence and function of metabotropic excitatory amino acid receptors (mGluR) in the frog semicircular canal (SCC). The mGluR agonist +/- 1-aminocyclopentane-trans-1,3-dicarboxylate (ACPD) produced an increase in afferent firing rates of the ampullar nerve of the intact posterior canal.
Paola Perin, Paola Perin, Meredith M. Garcia, Paul S. Guth, G. Zucca, Paolo Valli, Amrita Puri, Laura Botta, Grace B. Athas, Joseph C. Holt   +9 more
openaire   +4 more sources

Effects of bromohomoibotenate on metabotropic glutamate receptors

NeuroReport, 1994
(S)-Bromohomoibotenic acid [(S)-BrHIbo] stereoselectively antagonized glutamate-stimulated phosphoinositide (PI) hydrolysis in baby hamster kidney (BHK) cells expressing mGluR1a in a competitive manner with an IC50 of 250 microM. However, (S)-BrHIbo did not inhibit (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced PI hydrolysis ...
Peter D. Suzdak, Christian Foged, Christian Thomsen, Anne Bau, Peter Faarup, Anders Kanstrup   +5 more
openaire   +3 more sources

Metabotropic Glutamate Receptors: Gatekeepers of Homeostasis

Journal of Neuroendocrinology, 2010
The capacity to appropriately respond to physiological challenges or perturbations in homeostasis is a requisite for survival. It is becoming increasingly clear that long‐lasting alterations in synaptic efficacy are a fundamental mechanism for modifying neuroendocrine and autonomic output. We review recent advances in our understanding of plasticity at
Jaideep S. Bains, J. B. Kuzmiski
openaire   +3 more sources

2008 Eruptions in metabotropic glutamate receptors

Neuropharmacology, 2008
[No abstract available]
NICOLETTI, Ferdinando, Graham Collingridge, Darryle Schoepp   +2 more
openaire   +4 more sources