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Modulation of Excitation by Metabotropic Glutamate Receptors

2007
Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Marylka Uusisaari, Thomas Knöpfel
openaire   +3 more sources

The metabotropic glutamate receptors: Structure and functions

Neuropharmacology, 1995
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
Jean-Philippe Pin, Robert M. Duvoisin
openaire   +2 more sources

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

Nature, 2021
Shuling Lin   +19 more
semanticscholar   +1 more source

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

Nature Neuroscience, 2016
N. L. Weilinger   +13 more
semanticscholar   +1 more source

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen   +2 more
exaly  

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

Nature, 2014
A. S. Doré   +12 more
semanticscholar   +1 more source

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