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Modulation of Excitation by Metabotropic Glutamate Receptors
2007Metabotropic glutamate receptors, in contrast to ionotropic glutamate receptors, do not form ion channels but instead affect intracellular chemical messenger systems. They couple via GTP-binding proteins ("G-proteins") to a variety of effectors such as ion channels and thus give glutamate, the major excitatory transmitter in the CNS, the ability to ...
Marylka Uusisaari, Thomas Knöpfel
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The metabotropic glutamate receptors: Structure and functions
Neuropharmacology, 1995Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
Jean-Philippe Pin, Robert M. Duvoisin
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Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
Nature, 2021Shuling Lin+19 more
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Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity
Nature Neuroscience, 2016N. L. Weilinger+13 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen+2 more
exaly
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
Nature, 2014A. S. Doré+12 more
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Metabotropic glutamate receptors
Pharmacology Biochemistry and Behavior, 2002openaire +3 more sources