Results 31 to 40 of about 39,446 (289)

Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels [PDF]

arXiv, 2022
Perhaps the most important question posed by brain research is: How the brain gives rise to the mind. To answer this question, we have primarily relied on the connectionist paradigm: The brain's entire knowledge and thinking skills are thought to be stored in the connections; and the mental operations are executed by network computations.
arxiv  

Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]

, 2018
We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe, Colamartino, Marco, Di Menna, Luisa, Fiori, Elena, Iacovelli, Luisa, Leuzzi, Vincenzo, Nardecchia, Francesca, Nicoletti, Ferdinando, Nistico, Robert, Orlando, Rosamaria, Pascucci, Tiziana, Piccinin, Sonia, Puglisi-Allegra, Stefano   +12 more
core   +2 more sources

Metabotropic Glutamate Receptors and Epileptogenesis

Epilepsy Currents, 2002
Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus.
Robert K. S. Wong, Riccardo Bianchi, Shih-Chieh Chuang   +2 more
openaire   +3 more sources

Optical control of metabotropic glutamate receptors [PDF]

Nature Neuroscience, 2013
G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Harald Janovjak, Harald Janovjak, Ehud Y. Isacoff, Dirk Trauner, Dirk Trauner, David Schoppik, Andreas Reiner, Benjamin M. Gaub, Joshua Levitz, Adam Hoagland, Philipp Stawski, Alexander F. Schier, Brian Kane, Carlos R. Pantoja   +13 more
openaire   +4 more sources

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma

Cell Death and Disease, 2021
Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph   +17 more
doaj   +1 more source

Anti-mGluR1 encephalitis: Case illustration and systematic review

Frontiers in Neurology, 2023
BackgroundThe literature for immune-mediated neurological disorders is evolving like no other field of neurological illnesses. Many new antibodies or disorders have been described in the last decade.
Osama Khojah, Osama Khojah, Osama Khojah, Seraj Makkawi, Seraj Makkawi, Seraj Makkawi, Saeed Alghamdi   +6 more
doaj   +1 more source

Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]

arXiv, 2022
Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv  

Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]

, 2016
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core   +2 more sources

Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit

eLife, 2016
Synaptic currents display a large degree of heterogeneity of their temporal characteristics, but the functional role of such heterogeneities remains unknown. We investigated in rat cerebellar slices synaptic currents in Unipolar Brush Cells (UBCs), which
Valeria Zampini, Jian K Liu, Marco A Diana, Paloma P Maldonado, Nicolas Brunel, Stéphane Dieudonné   +5 more
doaj   +1 more source

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators

Frontiers in Molecular Biosciences, 2022
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events.
Paula Morales, Chanté Muller, Nadine Jagerovic, Patricia H. Reggio   +3 more
doaj   +1 more source