Results 61 to 70 of about 81,931 (247)

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
A. A. Freitas, A. Secker, Attwood, Bhasin, Bhasin, Bissantz, Cardoso, Christopoulos, D. R. Flower, Das, Davies, Flower, Flower, Foord, Gether, Gloriam, Guo, Horn, H  bert, J. Timmis, Karchin, Keerthi, Klabunde, Kolakowski, Lapinsh, M. Mendao, M. N. Davies, Milligan, Papasaikas, Prabhu, Sandberg, Schi  th   +31 more
core   +2 more sources

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source

AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells

Frontiers in Cellular Neuroscience, 2019
Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
doaj   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj  

Protein synthesis at synaptic sites on dendrites [PDF]

, 2001
Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
core   +1 more source

Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review

Frontiers in Immunology
Metabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Yixin Gu, Yixin Gu, Tingting Xuan, Tingting Xuan, Pankui Li, Pankui Li, Jing Zhou, Jing Zhou, Zhenhai Wang, Zhenhai Wang   +9 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source