Results 131 to 140 of about 37,316 (268)
Oncological Outcomes of Salvage Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma
Head &Neck, Volume 48, Issue 6, Page 1668-1676, June 2026.ABSTRACT Objective
To evaluate oncological outcomes and their predictors following salvage oropharyngectomy. Methods
This single‐center retrospective study included patients who underwent a salvage oropharyngectomy in an irradiated neck for recurrent or metachronous oropharyngeal squamous cell carcinoma (OPSCC) between 2014 and 2023.Jade Saykaly, Sébastien Vergez, Agnès Dupret‐Bories, Anouchka Modesto, Benjamin Vairel, Jérôme Sarini, Aurore Siegfried, Ana Cavillon, Emilien Chabrillac +8 morewiley +1 more sourcepH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM. [PDF]
, 2019 The urea channel of Helicobacter pylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-Cui, Yanxiang, Munson, Keith, Sachs, George, Strugatsky, David, Wen, Yi, Zhou, Kang, Zhou, Z Hong +6 morecore +1 more sourceSpontaneous Middle Cranial Fossa Cerebrospinal Fluid Leaks and Intracranial Hypertension: Systematic Review With Meta‐Analysis
Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.ABSTRACT Introduction
The perioperative management of spontaneous cerebrospinal fluid leaks (sCSFL) of lateral skull base remains under debate. We systematically synthesized and evaluated the current literature, to investigate the perioperative cranial‐pressure assessment protocols and relief methods.Georgios Vavoulis, Dimitrios Spinos, Panagiotis Varoutis, Georgios Georgountzos, Nina Rafailia Karela, Georgios Geropoulos, Jameel Muzaffar, Wai Sum Cho +7 morewiley +1 more sourcePresumed TP53 mosaicism: variants detected using a NGS hereditary cancer multigene panel [PDF]
, 2019 Aims/Context: NGS multigene panels are routinely used to identify germline pathogenic variants in cancer susceptibility genes. In addition, NGS allows the identification of low-level mosaicism events that may not be detectable by conventional Sanger ...Gonçalves, João, Rodrigues, Márcia, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís +5 morecore Impact of the Nadir Androgen Receptor Signaling Inhibitor‐Derived Integrative Response Model in Real‐World Patients With Metastatic Castration‐Sensitive Prostate Cancer
The Prostate, Volume 86, Issue 9, Page 1053-1060, June 15, 2026.ABSTRACT Background
Early deep prostate‐specific antigen (PSA) decline after the initiation of androgen receptor signaling inhibitor (ARSI) therapy is associated with favorable long‐term outcomes in metastatic castration‐sensitive prostate cancer (mCSPC).Kazuma Yukihiro, Yohei Sekino, Keisuke Goto, Kohei Saito, Kenta Fujiyama, Yoshito Kagiyama, Yoshimasa Kurimura, Kenichiro Fukuoka, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata +14 morewiley +1 more sourceDistribution and prognostic value of T‐cells in primary colorectal cancer and adjacent non‐tumor mucosa in stage IV versus stage I–III patients
International Journal of Cancer, Volume 158, Issue 10, Page 2760-2770, 15 May 2026.What's New?
While colonic mucosa lymphocytes have been quantified in the context of inflammatory diseases, T‐cells in non‐tumor mucosa adjacent to colorectal cancer remain understudied. This study found that in stage IV colorectal cancer (synchronous liver metastasis), higher Foxp3+ T‐cell density and Foxp3+/CD4+ and Foxp3+/CD8+ T‐cell ratios in non ...Esraa Ali, Wenjing Ye, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, Ondřej Daum, Václav Liška, Kari Hemminki, Andriy Trailin +10 morewiley +1 more sourceIMMUNOREACT 9 metachronous rectal cancers have high HLA-ABC expression on healthy epithelium but a lower infiltration of CD3+ T cells than primary lesions
Scientific ReportsLynch syndrome is rarely associated with rectal cancer (RC) and thus, metachronous RC has been scarcely investigated. This study aimed to analyze the mucosal immune microenvironment in sporadic and metachronous RC.Beatrice Salmaso, Melania Scarpa, Valerio Pellegrini, Astghik Stepanyan, Roberta Salmaso, Andromachi Kotsafti, Federico Scognamiglio, Dario Gregori, Giorgio Rivella, Ottavia De Simoni, Giulia Becherucci, Silvia Negro, Chiara Vignotto, Gaya Spolverato, Cesare Ruffolo, Imerio Angriman, Francesca Bergamo, Valentina Chiminazzo, Isacco Maretto, Maurizio Zizzo, Francesco Marchegiani, Luca Facci, Stefano Brignola, Gianluca Businello, Laurino Licia, Vincenza Guzzardo, Luca Dal Santo, Ceccon Carlotta, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Paolo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Giulia Pozza, Mario Godina, Giovanni Pirozzolo, Alfonso Recordare, Isabella Mondi, Corrado Da Lio, Roberto Merenda, Giovanni Bordignon, Daunia Verdi, Luca Saadeh, Silvio Guerriero, Alessandra Piccioli, Giulia Noaro, Roberto Cola, Giuseppe Portale, Chiara Cipollari, Matteo Zuin, Salvatore Candioli, Laura Gavagna, Fabio Ricagna, Monica Ortenzi, Mario Guerrieri, Giovanni Tagliente, Monica Tomassi, Umberto Tedeschi, Andrea Porzionato, Marco Agostini, Riccardo Quoc Bao, Francesco Cavallin, Gaia Tussardi, Barbara Di Camillo, Romeo Bardini, Ignazio Castagliuolo, Salvatore Pucciarelli, Matteo Fassan, Marco Scarpa +72 moredoaj +1 more source