Results 261 to 270 of about 746,734 (318)

A Pan‐Cancer Microenvironment Atlas Constructed by DECEPTICONx

open access: yesiMetaMed, EarlyView.
DECEPTICONx builds the most comprehensive pan‐cancer TME atlas to date from > 11,000 TCGA samples using 535,665 single cells, revealing 102 immune/stromal subtypes with robust novel associations to patient outcomes, immunotherapy response, and intercellular coordination in the TME.
Yida Gu   +14 more
wiley   +1 more source

MicrobTiSDA: A flexible R package for inferring interspecies interactions and abundance dynamics in microbiome time‐series data

open access: yesiMetaOmics, EarlyView.
MicrobTiSDA is a user‐friendly and flexible R package specifically designed for longitudinal microbiome data analysis. By integrating process‐oriented functional modules—including data input, data preprocessing, interspecies interaction inference, natural spline regression modeling, temporal pattern clustering, and random forest classification ...
Shijia Li   +5 more
wiley   +1 more source

Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries

open access: yesiMetaOmics, EarlyView.
Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo   +9 more
wiley   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

open access: yesiMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang   +6 more
wiley   +1 more source

Making genomic data FAIR through effective Data Portals. [PDF]

open access: yesSci Data
Speir ML   +11 more
europepmc   +1 more source

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

open access: yesiMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang   +72 more
wiley   +1 more source

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