Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model
Advanced Science, EarlyView.Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis +7 more
wiley +1 more source
Designing learning object repositories : a thesis presented in partial fulfilment of the requirements for the degree of Master of Information Science in Information Sciences at Massey University [PDF]
, 2006 Learning object repositories are expanding rapidly into the role of independent educational systems that not only are a supplement to a traditional way of learning, but also allow users to search, exchange and re-use learning objects.
Gan, Yang Yang
core
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
Using XML Schema with Embedded Schematron Rules for MODS Quality Control in a Digital Repository
Code4Lib Journal, 2018 The Michigan State University Libraries Digital Repository relies primarily on MODS descriptive metadata to convey meaning to users and to improve discoverability and access to the libraries’ unique information resources. Because the repository relies on
Lisa Lorenzo
doaj
International Journal of Digital Curation, 2018 This research study compared four academic libraries’ approaches to curating the metadata of dataset submissions in their institutional repositories and classified them in one of four categories: no curation, pre-ingest curation, selective curation, and ...
Amy Koshoffer +3 more
doaj +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
A generic framework for the development of standardised learning objects within the discipline of construction management [PDF]
, 2007 E-learning has occurred in the academic world in different forms since the early 1990s. Its use varies from interactive multimedia tools and simulation environments to static resources within learning management systems. E-learning tools and environments
Ahmed, V, Aouad, GF, Pathmeswaran, R
core +1 more source
AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering
Advanced Science, EarlyView.AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun +13 more
wiley +1 more source
Metadata Extraction and Management in Data Lakes With GEMMS
Complex Systems Informatics and Modeling Quarterly, 2016 In addition to volume and velocity, Big data is also characterized by its variety. Variety in structure and semantics requires new integration approaches which can resolve the integration challenges also for large volumes of data.
Christoph Quix, Rihan Hai, Ivan Vatov
doaj +1 more source
Open Access Metadata for Journals in Directory of Open Access Journals: Who, How, and What Scheme? [PDF]
, 2016 Open access (OA) is a form of publication that allows some level of free access to scholarly publications. The Directory of Open Access Journals (DOAJ) is a repository to which OA journals may apply and upload content to increase discoverability. OA also
Cheby, Lisa E
core +1 more source