Results 1 to 10 of about 50 (46)
Metagenomics and antibiotics [PDF]
Clinical Microbiology and Infection, 2012 Most of the bacterial species that form part of the biosphere have never been cultivated. In this situation, a comprehensive study of bacterial communities requires the utilization of non-culture-based methods, which have been named metagenomics.
Garmendia, L. +3 more
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DNA Research, 2022 Abstract Various microorganisms exist in environments, and each of which has an optimal growth temperature (OGT). The relationship between genomic information and OGT of each species has long been studied, and one such study revealed that OGT of prokaryotes can be accurately predicted based on the fraction of seven ...
Masaomi Kurokawa +6 more
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Nature Reviews Genetics, 2019 Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly moving from research to clinical laboratories. This emerging approach is changing how physicians diagnose and treat infectious disease, with applications spanning a wide range of ...
Charles Y. Chiu, Steven A. Miller
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PLoS Computational Biology, 2010 Metagenomics is a discipline that enables the genomic study of uncultured microorganisms. Faster, cheaper sequencing technologies and the ability to sequence uncultured microbes sampled directly from their habitats are expanding and transforming our view of the microbial world.
Bourne, Philip E. +3 more
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Metagenomics and probiotics [PDF]
Clinical Microbiology and Infection, 2012 The development of extensive sequencing methods has allowed metagenomic studies on the human gut microbiome to be carried out. This has tremendously increased our knowledge on gut microbiota composition and activity, allowing microbiota aberrations related to different diseases to be identified.
Gueimonde Fernández, Miguel +1 more
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Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software [PDF]
Nature Methods, 2017 ISSN:1548 ...
Sczyrba, Alexander +66 more
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Reviews in Medical Virology, 2007 AbstractCharacterisation of new viruses is often hindered by difficulties in amplifying them in cell culture, limited antigenic/serological cross‐reactivity or the lack of nucleic acid hybridisation to known viral sequences. Numerous molecular methods have been used to genetically characterise new viruses without prior in vitro replication or the use ...
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A Bioinformatician's Guide to Metagenomics [PDF]
Microbiology and Molecular Biology Reviews, 2008 SUMMARYAs random shotgun metagenomic projects proliferate and become the dominant source of publicly available sequence data, procedures for the best practices in their execution and analysis become increasingly important. Based on our experience at the Joint Genome Institute, we describe the chain of decisions accompanying a metagenomic project from ...
Kunin, V. +4 more
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PLoS ONE, 2014 Next generation sequencing technologies led to the discovery of numerous new microbe species in diverse environmental samples. Some of the new species contain genes never encountered before. Some of these genes encode proteins with novel functions, and some of these genes encode proteins that perform some well-known function in a novel way.
Szalkai, Balázs +4 more
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Translational metagenomics [PDF]
Journal of Translational Medicine, 2021 Selvasankar Murugesan +1 more
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