Results 101 to 110 of about 72,279 (314)

Unveiling Origin Pitfalls in Metagenomic Surveillance for Emerging Infectious Diseases: Parvoviruses as a Model

iMetaMed, EarlyView.
A diverse reagent‐associated virome, including parvoviruses, misleads zoonotic surveillance. By leveraging large language models (ChatGPT‐4o), we construct a virus discovery data framework (PVDDC) and ParvoDB to access and correct host misattributions, thereby enhancing the accuracy of metagenomic surveillance for emerging zoonotic diseases.
Peng Zhao, Jie Dong, Hong Liu, Data Research and Curation Team, Ying Xue, Ting Zhang, Hongtao Sui, Yongfeng Hu, Jiang Du, Haoxiang Su, Qi Jin, Fan Yang   +11 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Effect of Probiotic Bacteria on the Gut Microbiome of Mice with Lipopolysaccharide-Induced Inflammation

Microorganisms
The role of lipopolysaccharide (LPS) in the development of diseases is clear, but the specific mechanisms remain poorly understood. This study aimed to investigate the microbiome aberrations in the guts of mice against the background of LPS, as well as ...
Mariya Gryaznova, Inna Burakova, Yuliya Smirnova, Polina Morozova, Egor Chirkin, Artem Gureev, Evgeny Mikhaylov, Olga Korneeva, Mikhail Syromyatnikov   +8 more
doaj   +1 more source

Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs

iMetaOmics, EarlyView.
This study successfully established gut microbiota‐humanized pigs, achieved human‐like remodeling of the serum metabolome, and uncovered transcriptional alterations in immune cell subsets. These findings advance our understanding of how human gastrointestinal microorganisms affect host metabolism and the immune function in a porcine model.
Zhaoqi Zhang, Yanan Xu, Kun Pang, Changhong Wu, Chenxu Zhao, Tong Lei, Jiayu Zhang, Tang Hai, Fangqing Zhao, Yong Zhao   +9 more
wiley   +1 more source

New directions and interactions in metagenomics research [PDF]

, 2006
Naomi Ward
openalex   +1 more source

BioMGCore: A toolkit for detection of biological metabolites in microbiome

iMetaOmics, EarlyView.
The keyword matching and gene proximity principles were used to accurately identify core gene clusters in microbial genomes. The metabolic gene clusters can be classified into different taxonomic groups according to Domain, Phylum, Class, Order, Family, Genus, and Species. BioMGCore can achieve batch statistics for secondary metabolites prediction.
Guang Yang, Guohao Yu, Qian Cui, Xueping Huang, Kexin Guo, Shulei Jia   +5 more
wiley   +1 more source

Modular automated high‐throughput isolation and phylogenetic identification of bacteria from complex microbiomes

iMetaOmics, EarlyView.
Metagenomic analysis can generate hypotheses about microbiome interactions and function, yet mechanistic understanding is only possible through precise experimentation manipulating its microbiota composition. The high‐throughput isolation of microbiome members thus represents a core resource in this field of research.
Rubén Chaboy‐Cansado, Silvia Talavera‐Marcos, Ramón Gallego‐Simón, Paula Cobeta, Gabriel Roscales, Alberto Rastrojo, Daniel Aguirre de Cárcer   +6 more
wiley   +1 more source

HiFi based metagenomic assembly strategy provides accuracy near isolated genome resolution in MAG assembly

iMetaOmics, EarlyView.
Recovering high‐contiguity, circular bacterial genomes from complex microbiomes (e.g., gut) is challenged by limitations of short‐read and error‐prone long‐read sequencing. This study comprehensively compares PacBio High‐Fidelity (HiFi) sequencing‐based metagenome‐assembled genomes (MAGs) against Illumina MAGs, Oxford Nanopore Technologies (ONT) MAGs ...
Feilong Deng, Yanhua Han, Minghui Li, Yunjuan Peng, Jianmin Chai, Guan Yang, Ying Li, Jiangchao Zhao   +7 more
wiley   +1 more source

INVITED REVIEW: Microbial ecology in the age of genomics and metagenomics: concepts, tools, and recent advances [PDF]

, 2006
Jianping Xu
openalex   +1 more source

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure

iMetaOmics, EarlyView.
Microplastic‐induced gut microbial enrichment was dominated by bacteria within Eubacteriales, correlated with the virome, and accompanied by colitis. The polyamine synthetic pathway was activated to maintain glutathionylspermidine homeostasis, concurrent with decreases in pathways involved in the production of energy and reactive oxygen species under ...
Guozhu Ye, Zeming Wu, Guoyou Chen, Xuyi Liu, Yifang Duan, Minghui Li, Qiansheng Huang   +6 more
wiley   +1 more source