Results 171 to 180 of about 149,337 (415)

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Identification of Prosthetic Joint Infection Pathogens Using a Shotgun Metagenomics Approach

Clinical Infectious Diseases, 2018
Background Metagenomic shotgun sequencing has the potential to change how many infections, particularly those caused by difficult-to-culture organisms, are diagnosed. Metagenomics was used to investigate prosthetic joint infections (PJIs), where pathogen
Matthew J. Thoendel, P. Jeraldo, K. Greenwood-Quaintance, J. Yao, N. Chia, A. Hanssen, M. Abdel, Robin Patel   +7 more
semanticscholar   +1 more source

Enzymatic Production of Opine‐type Chiral Amines with Controlled Stereoselectivity

ChemCatChem, Accepted Article.
Chiral secondary amine dicarboxylic acid derivatives are key building blocks of several peptidomimetic angiotensin‐converting enzyme (ACE2) inhibitors. Reductive amination of α‐keto acids with α‐amino esters can yield orthogonally functionalized derivatives facilitating further chemical modifications. Biocatalysis offers a sustainable and selective way
András Telek, Gergő Dargó, Regina Kovács, Zsófia Molnár, Beáta G. Vértessy, Gábor Tasnádi   +5 more
wiley   +1 more source

Long Term Weight Cycling Affects Fecal Microbiota of Mice

Molecular Nutrition &Food Research, Volume 66, Issue 23, December 2022., 2022
Fighting obesity through dieting is not always sustained and results in a subsequent weight gain, a phenomenon referred to as weight cycling. We determined whether weight cycling affects mouse fecal bacteria on a long‐term basis. Compared to continuous High Fat (HF) or Low Fat (LF) diets, cyclic diet specifically alters the composition and function of ...
Christèle Humblot, Yohannes Seyoum, Williams Turpin, Rachida Mrabt, Edward O. List, Darlene E. Berryman, Elizabeth A. Jensen, Elahu G. Sustarsic, John J. Kopchick, Jean‐Marc Ricort   +9 more
wiley   +1 more source

Utilizing de Bruijn graph of metagenome assembly for metatranscriptome analysis [PDF]

arXiv, 2015
Metagenomics research has accelerated the studies of microbial organisms, providing insights into the composition and potential functionality of various microbial communities. Metatranscriptomics (studies of the transcripts from a mixture of microbial species) and other meta-omics approaches hold even greater promise for providing additional insights ...
arxiv  

Metagenomics-enabled microbial surveillance

Nature Microbiology, 2022
Karrie K. K. Ko, Kern Rei Chng, N. Nagarajan   +2 more
semanticscholar   +1 more source

One‐Pot Depolymerization of Mixed Plastics Using a Dual Enzyme System

ChemSusChem, EarlyView.
The concurrent depolymerization of a polymer blend comprising three hydrolyzable plastics is demonstrated by employing an esterase and a urethanase in a sequential one‐pot process. The reaction resulted in a depolymerization degree of around 40 %, which corresponds to a minimum monomer yield of 3 % for 4,4′‐methylenedianiline (MDA) and a maximum of 55 %
Yannick Branson, Jiawei Liu, Louis Schmidt, Jan Griebel, Andrea Prager, Lena Stieler, Daniel Breite, Thomas Bayer, Werner Besenmatter, Weiliang Dong, Ulrike Garscha, Uwe T. Bornscheuer, Ren Wei   +12 more
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Illumina Sequencing Artifacts Revealed by Connectivity Analysis of Metagenomic Datasets [PDF]

arXiv, 2012
Sequencing errors and biases in metagenomic datasets affect coverage-based assemblies and are often ignored during analysis. Here, we analyze read connectivity in metagenomes and identify the presence of problematic and likely a-biological connectivity within metagenome assembly graphs.
arxiv