Results 31 to 40 of about 166,453 (198)

Extrusion - back to the future: using an established technique to reform automated chemical synthesis [PDF]

, 2016
YesHerein, the benefits which extrusion can provide for the automated continuous synthesis of organic compounds are highlighted. Extrusion is a well-established technique that has a vital role in the manufacturing processes of polymers, pharmaceuticals ...
Crawford, Deborah E.
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Computational screening study towards redox-active metal-organic frameworks [PDF]

, 2013
The metal-organic framework (MOF) MFU-4l containing Co(II) centers and Cl- ligands has recently shown promising redox activity. Aiming for further improved MOF catalysts for oxidation processes employing molecular oxygen we present a density-functional ...
Denysenko, Dmytro, Jelic, Jelena, Reuter, Karsten, Volkmer, Dirk   +3 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Metal-organic frameworks as selective or chiral oxidation catalysts [PDF]

, 2014
Since the discovery of Metal Organic Frameworks (MOFs) in the early 1990s, the amount of new structures has grown exponentially. A MOF typically consists of inorganic nodes that are connected by organic linkers to form crystalline, highly porous ...
Leus, Karen, Liu, Ying-Ya, Van Der Voort, Pascal   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modeling Lewis catalyzed reactions in Metal Organic Frameworks [PDF]

, 2011
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Cottenie, Stijn, De Vos, Dirk, Van Speybroeck, Veronique, Vandichel, Matthias, Vermoortele, Frederik, Waroquier, Michel   +5 more
core   +1 more source

Advances in ab-initio theory of Multiferroics. Materials and mechanisms: modelling and understanding

, 2012
Within the broad class of multiferroics (compounds showing a coexistence of magnetism and ferroelectricity), we focus on the subclass of "improper electronic ferroelectrics", i.e.
A. Girlando, A. Malashevic, A. Rohrbach, A. Savin, A. Seidl, A. Stroppa, A. Stroppa, A. Stroppa, A. Stroppa, A. Stroppa, A.D. Becke, A.K. Cheetham, A.K. Kirov, A.P. Kuzmenko, A.P. Levanyuk, A.V. Kimel, B. Lorenz, B.J. Campbell, C. Adamo, C. Capillas, C. Capillas, C. Capillas, C. Ederer, C. Ederer, C. Loschen, C.N.R. Rao, D. Baldomir, D. Khomskii, D. Orobengoa, D. Vanderbilt, D.I. Khomskii, D.V. Efremov, E. Bousquet, E. Bousquet, E. Kroumova, E. Kroumova, E. Kroumova, E. Kroumova, E.J.W. Verwey, E.M. Wheeler, F. Hong, F. Kagawa, F. Kagawa, F. Kubel, F. Nad, G. Férey, G. Férey, G. Giovannetti, G. Giovannetti, G. Giovannetti, G. Giovannetti, G. Giovannetti, G. King, G. King, G. King, G. King, G. King, G. Kresse, G. Kresse, G. Kresse, G. Lawes, G. Rogez, G.P. Vorobev, H. Katsura, H. Okamoto, H. Schmidt, H. Tsunetsugu, H. Wu, H.F. Clausen, I.A. Sergienko, I.A. Sergienko, I.B. Bersuker, I.J. Dzialoshinski, I.V. Solovyev, J. Adhish, J. Brink van den, J. Hemberger, J. Heyd, J. Heyd, J. Hong, J. Kanamori, J. Lopez-Prez, J. Paier, J. Valasek, J. Wang, J.A. Alonso, J.B. Goodenough, J.B. Torrance, J.B. Torrance, J.F. Scott, J.H. Lee, J.L. Garcia-Munoz, J.M. Perez-Mato, J.M. Perez-Mato, J.M. Perez-Mato, J.M. Rondinelli, J.M. Rondinelli, J.M. Rondinelli, J.M. Rondinelli, J.P. Perdew, K. Yamauchi, K. Yamauchi, K. Yamauchi, K. Yamauchi, K.-L. Hu, K.-L. Hu, K.I. Kugel, L. Holmes, L. Neel, L. Noodleman, L. Noodleman, L. Noodleman, L. Noodleman, L.C. Chapon, M. Alexe, M. Belakhovsky, M. Cointe Le, M. Dressel, M. Filatov, M. Marsman, M. Matsubara, M. Mostovoy, M. Reehuis, M.A. black, M.I. Aroyo, M.I. Aroyo, M.J. Rosseinsky, M.T. Fernandez-Diaz, M.W. Licurse, N. Keller, N.A. Benedek, N.A. Benedek, N.A. Hill, N.A. Spaldin, N.B. Perkins, N.J. Mosey, O. Tchernyshyov, O.M. Yaghi, P. Barone, P. García, P. Ghosez, P. Hohenberg, P. Jain, P.E. Blochl, P.J. Hay, P.J. Stephens, P.W. Anderson, P.W. Anderson, P.W. Anderson, R. Ramesh, R. Ramesh, R. Resta, R. Valdes-Aguilar, R. Wojciechowski, R.D. King-Smith, R.E. Cohen, R.L. Withers, S. Blanco-Canosa, S. Garcia-Martin, S. Garcia-Martin, S. Horiuchi, S. Horiuchi, S. Horiuchi, S. Horiuchi, S. Ishibashi, S. Ishiwata, S. Ivantchev, S. Ivantchev, S. Kummel, S. Picozzi, S. Picozzi, S. Picozzi, S. Valencia, S. Weber, S.C. Parida, S.J. Luo, S.L. Gnatchenko, S.W. Cheong, T. Fukushima, T. Fukushima, T. Fukushima, T. Hoffmann, T. Kimura, T. Kurumaji, T. Moriya, T. Smith, T. Zhao, T.-Y. Khim, V. Pardo, V.I. Anisimov, V.I. Anisimov, V.Y. Pomjakushin, W. Dachraoui, W. Kohn, X.-Y. Wang, Y. Du, Y. Miyamoto, Y. Nakatsuka, Y. Okimoto, Y. Takano, Y. Tokunaga, Y. Tokunaga, Y. Tokura, Y. Yamasaki, Z.G. Soos   +204 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source