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The preparation of stable complexes between the N7-[2-(2-pyridyl)ethyl] and N7-(2-piperazinylethyl) derivatives of mitomycin C and metal ions such as Cu(II), Zn(II), and Pt(II) was accomplished. Mitomycin C did not form stable complexes, but it rearranged to a mitosene capable of complex formation. Some of these complexes had antitumor activity in mice.
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Metal Complexes of Dithiatetrazocines
Phosphorus, Sulfur, and Silicon and the Related Elements, 1992Abstract Dithiatetrazocines of the type 1,5-E2N4S2 (E=Me2NC, R2P) form the transition metal complexes M(PR3)2(1,5-E2N4S2) (M=Pt, Pd, Ni) which involve an η2- S, S′ interaction with the metal. A reversible elimination of R3P from these mononuclear complexes gives the binuclear complexes [M(PR3)(1,5-E2N4S2)]2.
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