Results 21 to 30 of about 194,330 (254)

Comparative Solution Equilibrium Studies on Anticancer Estradiol-Based Conjugates and Their Copper Complexes

Inorganics
Steroids are often considered valuable molecular tools for the development of anticancer agents with improved pharmacological properties. Conjugation of metal chelating moieties with a lipophilic sterane backbone is a viable option to obtain novel ...
Éva A. Enyedy, Anett Giricz, Tatsiana V. Petrasheuskaya, János P. Mészáros, Nóra V. May, Gabriella Spengler, Ferenc Kovács, Barnabás Molnár, Éva Frank   +8 more
doaj   +1 more source

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Journal of Analytical Science and Technology, 2018
Background The drug-metal complexes are used to control the growth of pathogens and parasites which are harmful to humans. Moxifloxacin (MOX) is a new fourth generation 8- methoxy fluoroquinolone.
Kondaiah Seku, Anil Kumar Yamala, Mahesh Kancherla, Kishore Kumar K, Vijayakumar Badathala   +4 more
doaj   +1 more source

Synthesis, Spectroscopic, Chemical Characterizations, Anticancer Capacities against HepG-2, Antibacterial and Antioxidant Activities of Cefotaxime Metal Complexes with Ca(II), Cr(III), Zn(II), Cu(II) and Se(IV)

Antibiotics, 2022
In this study, metal cefotaxime complexes of Ca(II), Cr(III), Cu(II), Zn(II), and Se(VI) were synthesized and characterized by elemental analysis, conductance measurements, IR, electronic spectra, magnetic measurements, 1HNMR, and XRD, as well as by ...
Eman H. Al-Thubaiti, Samy M. El-Megharbel, Bander Albogami, Reham Z. Hamza   +3 more
doaj   +1 more source

The application of HP-GFC chromatographic method for the analysis of oligosaccharides in bioactive complexes [PDF]

Hemijska Industrija, 2009
The aim of this work was to optimize a GFC method for the analysis of bioactive metal (Cu, Co and Fe) complexes with olygosaccharides (dextran and pullulan). Bioactive metal complexes with olygosaccharides were synthesized by original procedure.
Savić Ivan, Nikolić Goran, Savić Ivana, Cakić Milorad   +3 more
doaj   +1 more source

Bis (Diamines) Cu and Zn Complexes of Flurbiprofen as Potential Cholinesterase Inhibitors: In Vitro Studies and Docking Simulations

Crystals, 2021
Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between the nerve cells and reducing the risk of dementia.
Muhammad Jamil, Nargis Sultana, Rizwan Ashraf, Maryam Bashir, Muhammad Fayyaz ur Rehman, Fariha Kanwal, Humna Ellahi, Changrui Lu, Wei Xing Zhang, Muhammad Ilyas Tariq   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Synthesis, Characterization and Antibacterial activities of Uracil and Uracil–Oxalate Complexes with Cr(III) and Fe(III) [PDF]

Engineering and Technology Journal, 2019
New complexes of the some trivalent transition metal ions of the uracil such as [M(Ura)3Cl3] and mixed ligand metal complexes with uracil and oxalic acid [M(Ura)2(OA)(OH2)Cl].H2O type, where (Ura)=Uracil, (OA= Oxalic acid dihydrate, (M= Cr+3 and Fe+3 ...
Shatha Obaid
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

In-silico DFT studies and molecular docking evaluation of benzimidazo methoxy quinoline-2-one ligand and its Co, Ni, Cu and Zn complexes as potential inhibitors of Bcl-2, Caspase-3, EGFR, mTOR, and PI3K, cancer-causing proteins

Chemical Physics Impact
We present here the design, Density Functional Theory (DFT) and Molecular Docking studies of Benzimidazo Methoxy Quinoline-2-one (BMQ) ligand-coordinated transition metal complexes (Co, Ni, Cu, and Zn).
K Kaavin, D Naresh, MR Yogeshkumar, M Krishna Prakash, S Janarthanan, M Murali Krishnan, M Malathi   +6 more
doaj   +1 more source