Metallochaperones regulate intracellular copper levels. [PDF]
, 2013 Copper (Cu) is an important enzyme co-factor that is also extremely toxic at high intracellular concentrations, making active efflux mechanisms essential for preventing Cu accumulation. Here, we have investigated the mechanistic role of metallochaperones
Adams, Michael +9 more
core +1 more source
Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
core +1 more source
mSphere of Influence: Intermetal Competition during Manganese Toxicity
mSphere, 2020 Julia E. Martin works in the field of metals in biology, with a focus on manganese (Mn) homeostasis in Streptococcus pneumoniae. In this mSphere of Influence article, she reflects on how the paper entitled “Role of the manganese efflux system mntE for ...
Julia E. Martin
doaj +1 more source
BiomoleculesThe serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia.
Jana Key +7 more
doaj +1 more source
Heavy metal bioaccumulation by the important food plant, olea europaea L., in an ancient metalliferous polluted area of Cyprus [PDF]
, 2007 Aspects of the bioaccumulation of heavy metals are reviewed and possible evidence of homeostasis is highlighted. Examination and analysis of olive (Olea europaea L.) trees growing in close proximity to a copper dominated spoil tip dating from at least ...
B Wilson +15 more
core +1 more source
Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity. [PDF]
, 2020 Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse
Antiparra, R +10 more
core +1 more source
Mechanisms of Metal Resistance and Homeostasis in Haloarchaea [PDF]
Archaea, 2013 Haloarchaea are the predominant microflora of hypersaline econiches such as solar salterns, soda lakes, and estuaries where the salinity ranges from 35 to 400 ppt. Econiches like estuaries and solar crystallizer ponds may contain high concentrations of metals since they serve as ecological sinks for metal pollution and also as effective traps for river
Srivastava, Pallavee, Kowshik, Meenal
openaire +3 more sources
Cadmium and arsenic-induced-stress differentially modulates Arabidopsis root architecture, peroxisome distribution, enzymatic activities and their nitric oxide content [PDF]
, 2020 In plant cells, cadmium (Cd) and arsenic (As) exert toxicity mainly by inducing oxidative stress through an imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and their detoxification. Nitric oxide (NO)
Altamura, M. M. +4 more
core +2 more sources
Lysosome-related Organelles as Mediators of Metal Homeostasis [PDF]
Journal of Biological Chemistry, 2014 Metal ion assimilation is essential for all forms of life. However, organisms must properly control the availability of these nutrients within the cell to avoid inactivating proteins by mismetallation. To safeguard against an imbalance between supply and demand in eukaryotes, intracellular compartments contain metal transporters that load and unload ...
Blaby-Haas, Crysten E +1 more
openaire +4 more sources
Cadmium and arsenic affect root development in Oryza sativa L. negatively interacting with auxin [PDF]
, 2018 Cadmium (Cd) and arsenic (As), non essential, but toxic, elements for animals and plants are frequently present in paddy fields. Oryza sativa L., a staple food for at least the half of world population, easily absorbs As and Cd by the root, and in this ...
Altamura, M. M. +7 more
core +2 more sources