Results 31 to 40 of about 197,339 (252)

Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper

Frontiers in Molecular Biosciences, 2022
Copper is an essential metal micronutrient with biological roles ranging from energy metabolism to cell signaling. Recent studies have shown that copper regulation is altered by fat accumulation in both rodent and cell models with phenotypes consistent ...
Nathaniel H. O. Harder, Hannah P. Lee, Valerie J. Flood, Jessica A. San Juan, Skyler K. Gillette, Marie C. Heffern   +5 more
doaj   +1 more source

CLPP-Null Eukaryotes with Excess Heme Biosynthesis Show Reduced L-arginine Levels, Probably via CLPX-Mediated OAT Activation

Biomolecules
The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In humans and mice, its loss causes Perrault syndrome, which presents with growth deficits, infertility, deafness, and ataxia.
Jana Key, Suzana Gispert, Arvind Reddy Kandi, Daniela Heinz, Andrea Hamann, Heinz D. Osiewacz, David Meierhofer, Georg Auburger   +7 more
doaj   +1 more source

Plant Frataxin in Metal Metabolism

Frontiers in Plant Science, 2018
Frataxin is a highly conserved protein from prokaryotes to eukaryotes. Several functions related to iron metabolism have been postulated for this protein, including Fe-S cluster and heme synthesis, response to oxidative damage and oxidative ...
Diego F. Gomez-Casati, Maria V. Busi, Maria A. Pagani   +2 more
doaj   +1 more source

The Impact of Chromate on Pseudomonas aeruginosa Molybdenum Homeostasis

Frontiers in Microbiology, 2022
Acquisition of the trace-element molybdenum via the high-affinity ATP-binding cassette permease ModABC is essential for Pseudomonas aeruginosa respiration in anaerobic and microaerophilic environments.
Eve A. Maunders, Dalton H. Y. Ngu, Dalton H. Y. Ngu, Dalton H. Y. Ngu, Katherine Ganio, Sheikh I. Hossain, Bryan Y. J. Lim, Bryan Y. J. Lim, Bryan Y. J. Lim, Michael G. Leeming, Zhenyao Luo, Zhenyao Luo, Zhenyao Luo, Aimee Tan, Evelyne Deplazes, Evelyne Deplazes, Boštjan Kobe, Boštjan Kobe, Boštjan Kobe, Christopher A. McDevitt   +19 more
doaj   +1 more source

Predicting copper-, iron- and zinc-binding proteins in pathogenic species of the Paracoccidioides genus

Frontiers in Microbiology, 2015
Approximately one-third of all proteins have been estimated to contain at least one metal cofactor, and these proteins are referred to as metalloproteins.
Gabriel B Tristao, Leandro Prado Assunção, Luiz Paulo Araujo Santos, CLAYTON LUIZ BORGES, Mirelle Garcia Silva-Bailao, Célia Maria de Almeida Soares, Gabriele eCavallaro, Alexandre Melo BAILAO   +7 more
doaj   +1 more source

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases

Biomolecules, 2014
The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown.
Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Haibo Wang, Istvan Boldogh, Kosagi Sharaf Rao, Sankar Mitra, Muralidhar L. Hegde   +7 more
doaj   +1 more source

Zinc translocation from Zn-sufficient to Zn-deficient roots as an adaptation to heterogeneous Zn availability

BMC Plant Biology
Zinc is essential for plant development and human health. While the effects of soil nutrient heterogeneity on plant growth were studied for macronutrients, adaptive mechanisms for micronutrients like Zn remain largely unexplored.
Magdalena Pypka, Diana Davydenko, Katarzyna Sowa, Julia Maksymiuk, Paweł Wróbel, Tomasz Kołodziej, Paweł Korecki, Oskar Siemianowski   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model

Molecules, 2021
Manganese (Mn) is a biologically essential metal, critical as a cofactor for numerous enzymes such a glutamine synthetase and kinases such as ataxia-telangiectasia mutated (ATM).
Kyle J. Horning, Xueqi Tang, Morgan G. Thomas, Michael Aschner, Aaron B. Bowman   +4 more
doaj   +1 more source