Results 31 to 40 of about 196,557 (347)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effect of Post Heat Treatment on the Microstructure and Microhardness of Friction Stir Processed NiAl Bronze (NAB) Alloy

Metals, 2015
NiAl bronze (NAB) alloy is prepared by using friction stir processing (FSP) technique at a tool rotation rate of 1200 rpm and a traverse speed of 150 mm/min. A post heat treatment is performed at the temperature of 675 °C. The effect of heat treatment on
Yuting Lv, Liqiang Wang, Xiaoyan Xu, Weijie Lu   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Advances in Joining Techniques Used in Development of SPF/DB Titanium Sandwich Reinforced with Metal Matrices [PDF]

, 1985
Three and four-sheet expanded titanium sandwich sheets have been developed at Douglas Aircraft Company, a division of McDonnell Douglas Corporation, under contract to NASA Langley Research Center.
Fischler, J. E.
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Confining iodide migration with quantified barrier for durable perovskite solar cells

Nature Communications
The migration of iodide ions out of the perovskite film degrades charge transport and electrode layers, reducing the long-term stability of perovskite solar cells.
Hongcai Tang, Yangzi Shen, Ge Yan, Liyuan Han, Qifeng Han   +4 more
doaj   +1 more source

Abnormal grain growth in randomly-oriented fine grains in an Al–Mg–Sc–Zr alloy processed by laser-powder-bed-fusion

Materials Research Letters
In this work, we report a counter-intuitive activation of abnormal grain growth (AGG) in randomly-oriented fine grains (FGs) in an L-PBF Al–Mg–Sc–Zr alloy, which is unlikely from perspectives of curvature-driven grain growth, crystallographic texture or ...
Yanchi Chen, Xiang Chen, Han Chen, Yakai Xiao, Jing Dai, Yidan Chen, Yuchi Cui, Chengyi Dan, Zhe Chen, Xianfeng Li, Haowei Wang   +10 more
doaj   +1 more source

Evaluation of Wear Properties of Flyash and C-Glass Reinforced Al4046 Hybrid MMC [PDF]

, 2014
Metal Matrix Composites (MMCs) are engineered materials designed by a combination of a particulate or fibre reinforced in a metal or alloy matrix. This research work is concerned about the production of Fly ash, C-glass reinforced hybrid Aluminium 4046 ...
Imran Khan, K.A., Shantharaja, M., Shivanand, H.K.   +2 more
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