Results 51 to 60 of about 540,832 (313)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Catalytic Methane Decomposition for the Simultaneous Production of Hydrogen and Low-Reactivity Biocarbon for the Metallurgic Industry

Energies
To reach agreed-on climate goals, it is necessary to develop new energy carriers and industrial materials that are carbon-neutral. To combat global warming and keep Earth’s temperature from increasing by 1.5 °C, some of these solutions need to be carbon ...
Roger A. Khalil, Sethulakshmy Jayakumari, Halvor Dalaker, Liang Wang, Pål Tetlie, Øyvind Skreiberg   +5 more
doaj   +1 more source

Comparison of Cattle Housing Systems Based on the Criterion of Damage to Barn Equipment and Construction Errors

Animals, 2022
Dairy cattle housing systems are the subject of numerous studies, in which a strong emphasis is placed on the comparison of animal welfare, animal behavior, production indicators and labor inputs.
Marek Gaworski, Michał Boćkowski
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Residual stresses in ceramic metal assembly after brazing process [PDF]

, 2006
The framework of this study is the thermo-mechanical analysis of the brazing process of ceramic metal assemblies. The thermal expansion gradient between ceramic and metallic materials leads to the development of residual stresses during the cooling phase
B. Lorrain, V. Cazajus, Karama, Moussa, Welemane, Hélène, H. Welemane, Moussa Karama, Lorrain, Bernard, Cazajus, Vincent   +7 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Practical Approbation of Thermodynamic Criteria for the Consolidation of Bimetallic and Functionally Gradient Materials

Metals, 2021
This study concerns the key problem of determining the conditions for the consolidation or fracture of bimetallic compounds and high-gradient materials with different coefficients of thermal expansion.
Alexander Khaimovich, Yaroslav Erisov, Anton Agapovichev, Igor Shishkovsky, Vitaliy Smelov, Vasilii Razzhivin   +5 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

The Role of Carbon in the Mechanism of Ferritic-Austenitic Cast Steel Solidification

Archives of Foundry Engineering, 2014
The paper presents the results of research on the microstructure of GX2CrNiMoCuN25-6-3-3 and GX2CrNiMoCuN25-6-3 cast steels with a varying carbon content.
Stradomski G.
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source