Results 21 to 30 of about 2,284 (265)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Metal–metal bonds in biology [PDF]
Journal of Inorganic Biochemistry, 2012 Nickel-containing carbon monoxide dehydrogenases, acetyl-CoA synthases, nickel-iron hydrogenases, and diron hydrogenases are distinct metalloenzymes yet they share a number of important characteristics. All are O(2)-sensitive, with active-sites composed of iron and/or nickel ions coordinated primarily by sulfur ligands.
openaire +2 more sources
Transferencia de metales suelo – planta en el cerro “El Toro”, Huamachuco, Perú
Manglar, 2019 En la minera informal del cerro “El Toro”, se establecieron tres puntos de muestreo, con la finalidad de determinar las plantas con potencial fitorremediaror, para ello se tomaron muestras de suelo superficial y se recolectaron plantas herbáceas ...
Narda Alarcón, Freddy Peláez
doaj +1 more source
Ge-conservación, 2021 Gracias a la revolución tecnológica que vive el campo de la documentación del patrimonio vemos cómo los registros 3D se consolidan como recurso documental y se extienden con infinidad de propósitos, entre ellos los estudios morfométricos.
Alba Fuentes Porto +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Aplicación de la nanofiltración y pervaporación en el tratamiento de aguas residuales
Tecnología en Marcha, 2016 Este trabajo trata sobre la aplicación de las tecnologías de membrana en el tratamiento de las aguas residuales o usadas. Las operaciones de membrana se aplican a numerosos problemas medioambientales como resultado de unas regulaciones más restrictivas ...
M. J. Mora +2 more
doaj +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
La terapia fotodinámica promete revolucionar el tratamiento del cáncer
Tecnociencia Chihuahua, 2023 El cáncer es una de las enfermedades que más afecta a la población mundial. Los tratamientos más aplicados son la cirugía, la radioterapia y la quimioterapia. La quimioterapia consiste en el uso de fármacos para destruir las células cancerosas.
Lucas Verget +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source