Results 31 to 40 of about 2,284 (265)

Niveles de contaminación del agua potable en la cabecera municipal de Ascención, Chihuahua, México

Nova Scientia, 2015
Introducción: El agua es una sustancia indispensable para la vida por lo que se considera como el recurso natural más apreciado en el planeta. En el norte de México existe el “Programa ambiental México-Estados Unidos: Frontera 2020”; en el cual ...
Héctor Osbaldo Rubio Arias, Lourdes Raquel Balderrama Terrazas, Eduviges Burrola Barraza, Guadalupe Nelson Aguilar Palma, Rubén Alfonso Saucedo Terán   +4 more
doaj   +1 more source

Efectos de las actividades antrópicas sobre parámetros metabólicos en un bivalvo invasor y otro nativo en el tramo inferior del río Paraná

Ecología Austral, 2022
La relación entre la contaminación antrópica, la geoquímica y la dinámica natural de los ecosistemas de agua dulce determinan patrones espaciales y temporales de calidad del agua. Las actividades humanas y la introducción de especies exóticas son causas
Tatiana Noya Abad, Julieta Peluso, Yanina S. Minaberry, Dante E. Rojas, Diego Cristos, Henrique Knack De Almeida, María S. Yusseppone, Carolina M. Aronzon, Javier Á. Calcagno, Sebastián E. Sabatini   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Metallic hydrogen [PDF]

Journal of Physics: Condensed Matter, 2018
Abstract Hydrogen is the simplest and most abundant element in the Universe. There are two pathways for creating metallic hydrogen under high pressures. Over 80 years ago Wigner and Huntington predicted that if solid molecular hydrogen was sufficiently compressed in the T   =
Ranga Dias, Isaac Silvera
openaire   +2 more sources

Distribución de Fe, Zn, Pb, Cu, Cd y As originada por residuos mineros y aguas residuales en un transecto del Río Taxco en Guerrero, México

Revista Mexicana de Ciencias Geológicas, 2013
El manejo inadecuado de los residuos del procesamiento de minerales es una de las principales fuentes de metales y arsénico hacia los ríos en los cuales pueden alcanzar niveles peligrosos para los seres humanos y los ecosistemas.
Miriam Méndez-Ramírez, María Aurora Armienta Hernández   +1 more
doaj  

Contenido de metales pesados en los peces en el Perú: una revisión sistémica

Revista de Investigación e Innovación Agropecuaria y de Recursos Naturales
La contaminación por metales pesados ​​en los ecosistemas acuáticos del Perú, derivada de actividades mineras, industriales y urbanas, representa un riesgo para la fauna y la salud humana.
Manuel Mamani Flores, Jessy Blas Alvarado, Sergio Izquierdo Villaverde, Cauper Gil Gonzales, Maritza Andrade Saavedra, Dina Pari Quispe   +5 more
doaj   +1 more source