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Design and Construction of Functional Supramolecular Metalloprotein Assemblies.
Accounts of Chemical Research, 2019Nature puts to use only a small fraction of metal ions in the periodic table. Yet, when incorporated into protein scaffolds, this limited set of metal ions carry out innumerable cellular functions and execute essential biochemical transformations such as
L. Churchfield, F. A. Tezcan
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2013
Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
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Paramagnetic metalloproteins are proteins containing one or more paramagnetic metal ions, which are characterized by the presence of at least one unpaired electron. As in every molecule, unpaired electrons sizably perturb the NMR parameters relative to the protein nuclei, changing their relaxation, chemical shift, and motional averaging so that ...
BERTINI, IVANO, PARIGI, GIACOMO
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Current Opinion in Biotechnology, 1996
The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
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The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal ...
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Molecular Carcinogenesis, 2019
Macrophage migration inhibitory factor (MIF) has been shown to closely associate with the malignant progression of a variety of human carcinomas. However, the role and its underlying molecular mechanisms of MIF in the invasion and metastasis of oral ...
Sha-Sha Wang +11 more
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Macrophage migration inhibitory factor (MIF) has been shown to closely associate with the malignant progression of a variety of human carcinomas. However, the role and its underlying molecular mechanisms of MIF in the invasion and metastasis of oral ...
Sha-Sha Wang +11 more
semanticscholar +1 more source
2009
While manganese has been successfully exploited as a spectroscopic probe of EPR silent centers (Zn, Ca, Mg) in metalloenzymes, it was only during the last decade that manganese-containing metalloenzymes were investigated in great detail. Indeed, in some biological systems it remains unclear whether iron and/or manganese is required for catalytic ...
Smith, Sarah J. +4 more
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While manganese has been successfully exploited as a spectroscopic probe of EPR silent centers (Zn, Ca, Mg) in metalloenzymes, it was only during the last decade that manganese-containing metalloenzymes were investigated in great detail. Indeed, in some biological systems it remains unclear whether iron and/or manganese is required for catalytic ...
Smith, Sarah J. +4 more
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Metalloproteins and metal sensing
Nature, 2009Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells.
Kevin J, Waldron +3 more
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2015
Preface: Metalloproteins play essential critical functional roles in enzymatically catalyzing reactions difficult to achieve without metals, in signal transduction, and in storage and transport of proteins constituting over 1/3 of the proteome of living organisms.
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Preface: Metalloproteins play essential critical functional roles in enzymatically catalyzing reactions difficult to achieve without metals, in signal transduction, and in storage and transport of proteins constituting over 1/3 of the proteome of living organisms.
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FTIR Spectroscopy of Metalloproteins
2014Absorption of infrared radiation by proteins gives important information about their structure and function. The most intense infrared bands correspond to the overlap of all the peptide bond absorption. Additionally, in many metalloproteins their prosthetic groups have intrinsic ligands or bind substrates/inhibitors that absorb intensively in the ...
Oscar, Gutiérrez-Sanz +2 more
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Metalloproteins and neuronal death
Metallomics, 2010Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very common and other diseases that are notorious but occur less often such as Creutzfeldt-Jakob disease. In each case a protein is closely linked to the pathology of these diseases. These proteins include alpha-synuclein, the prion protein and Aβ.
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