Results 281 to 290 of about 21,893 (312)

Metalloprotein Inhibitors for the Treatment of Human Diseases.

Current Topics in Medicinal Chemistry, 2015
Metalloproteins have attracted momentous attentions for the treatment of many human diseases, including cancer, HIV, hypertension, etc. This article reviews the progresses that have been made in the field of drug development of metalloprotein inhibitors,
Yang Yang, Xue-Qin Hu, Qingshan Li, Xing-Xing Zhang, B. Ruan, Jun Xu, Chenzhong Liao   +6 more
semanticscholar   +1 more source

An Accurate Metalloprotein-Specific Scoring Function and Molecular Docking Program Devised by a Dynamic Sampling and Iteration Optimization Strategy

Journal of Chemical Information and Modeling, 2015
Metalloproteins, particularly zinc metalloproteins, are promising therapeutic targets, and recent efforts have focused on the identification of potent and selective inhibitors of these proteins.
Fang Bai, Sha Liao, Junfeng Gu, Hualiang Jiang, Xicheng Wang, Honglin Li   +5 more
semanticscholar   +1 more source

Metalloprotein-Inspired Ruthenium Polymeric Complex: A Highly Efficient Catalyst in Parts per Million Level for 1,3-Dipolar Huisgen’s Reaction in Aqueous Medium at Room Temperature

, 2017
The metalloprotein-inspired Ru complex (3) was prepared via molecular convolution from linear amphiphilic polymer poly(N-isopropylacrylamide-co-N-vinylimidazole) (1) and ruthenium trichloride (2). The insoluble black metalloprotein-inspired Ru complex (3)
Ashish Gupta, Ramen Jamatia, M. Mahato, A. Pal   +3 more
semanticscholar   +1 more source

Handbook of Metalloproteins

2006
Volume 1 IRON Heme Proteins: Oxygen Storage and Oxygen Transport Proteins Heme Proteins: Cytochromes Heme Proteins: Cytochrome Peroxidases Heme Proteins: Cytochrome P-450 Heme Proteins: Oxidoreductases Non-Heme Proteins: Iron-Sulfur Clusters Non-Heme Proteins: Mononuclear Iron Proteins Volume 2 IRON continued Non-Heme Proteins: Dinuclear Iron Proteins ...
Albrecht Messerschmidt, Karl Wieghardt, Thomas Poulos, Robert Huber   +3 more
openaire   +3 more sources

A supramolecular assembly enables discrimination between metalloproteins and non-metalloproteins

Chemical Communications, 2018
A supramolecular assembly yields turn-on fluorescence response for non-metalloproteins and turn-off response for metalloproteins.
Aafrin M. Pettiwala, Prabhat K. Singh, Prabhat K. Singh   +2 more
openaire   +3 more sources

Metalloprotein design using genetic code expansion.

Chemical Society Reviews, 2014
More than one third of all proteins are metalloproteins. They catalyze important reactions such as photosynthesis, nitrogen fixation and CO2 reduction. Metalloproteins such as the olfactory receptors also serve as highly elaborate sensors. Here we review
Cheng Hu, S. Chan, Elizabeth B. Sawyer, Yang Yu, Jiangyun Wang   +4 more
semanticscholar   +1 more source

Perspectives in paramagnetic NMR of metalloproteins

Dalton Transactions, 2008
NMR experiments and tools for the characterization of the structure and dynamics of paramagnetic proteins are presented here. The focus is on the importance of (13)C direct-detection NMR for the assignment of paramagnetic systems in solution, on the information contained in paramagnetic effects observed both in solution and in the solid state, and on ...
BERTINI, IVANO, LUCHINAT, CLAUDIO, PARIGI, GIACOMO, PIERATTELLI, ROBERTA   +3 more
openaire   +3 more sources

Engineering and design in the bioelectrochemistry of metalloproteins

Current Opinion in Structural Biology, 2001
Engineered metalloproteins offer interesting systems for electrochemical studies of protein structure/function and their applications in nanobiotechnology. Scanning probe microscopy and cyclic voltammetry of engineered metalloproteins and electrodes have proved to be a powerful combination of tools contributing to the field of bioelectrochemistry.
GILARDI, Gianfranco, SADEGHI, JILA, FANTUZZI A.   +2 more
openaire   +4 more sources

NMR Spectroscopy of Paramagnetic Metalloproteins

ChemBioChem, 2005
AbstractThis article deals with the solution structure determination of paramagnetic metalloproteins by NMR spectroscopy. These proteins were believed not to be suitable for NMR investigations for structure determination until a decade ago, but eventually novel experiments and software protocols were developed, with the aim of making the approach ...
BERTINI, IVANO, LUCHINAT, CLAUDIO, PARIGI, GIACOMO, PIERATTELLI, ROBERTA   +3 more
openaire   +4 more sources

Electrochemistry of single metalloprotein and DNA-based molecules at Au(111) electrode surfaces.

ChemPhysChem, 2013
We have briefly overviewed recent efforts in the electrochemistry of single transition metal complex, redox metalloprotein, and redox-marked oligonucleotide (ON) molecules.
P. Salvatore, Dongdong Zeng, Kasper K. Karlsen, Q. Chi, Jesper Wengel, J. Ulstrup   +5 more
semanticscholar   +1 more source